Wpływ tamoksifenu na platynowrażliwość i ekspresję receptorów estrogenowych linii komórkowych raka jajnika

Translated title of the contribution: Influence of tamoxifen on cisplatin-sensitivity and estrogen receptors expression in ovarian carcinoma cell lines

Nowak Markwitz Ewa, Maciejczyk Adam, Pudełko Marek, Tserenchunt Gansukh, Balázs Györffy, Spaczyński Marek, Zabel Maciej, Dietel Manfred, Lage Hermann, Surowiak Paweł

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Tamoxifen, used in breast cancer treatment, competitively inhibits estrogen receptor (ER) and also demonstrates direct antiproliferative effect on cancer cells even in ER lacking cancer tissue. However, its molecular mechanism of action is still unclear. Material and methods: We exposed on tamoxifen 11 ovarian cancer cell lines, including well-documented platinumsensitive and platinum-resistant ones, and studied tamoxifen-, cisplatin-sensitivity and expression of ERα and ß. Results: We observed: no correlation between TAM-sensitivity and ERα and ERβ expressions, no correlation between TAM influence on cisplatin-sensitivity and ERα and ERβ expressions, increase of ERβ expression after TAM-exposure in 3 cell lines; decrease in the 1 line, no TAM-exposure influence on ERα expression and increase of IC50 for cisplatin after TAM-exposure in 5 (45%) cell lines. These results show ovarian cancer cells being affected by TAM have different platinum sensitivity. Conclusions: Our data suggests that ovarian cancer cells platinum-sensitivity are not linked with ER expressions. We claim the necessity of seeking some TAM predicting factors, using DNA microarrays.

Translated title of the contributionInfluence of tamoxifen on cisplatin-sensitivity and estrogen receptors expression in ovarian carcinoma cell lines
Original languagePolish
Pages (from-to)183-187
Number of pages5
JournalGinekologia Polska
Volume81
Issue number3
Publication statusPublished - Mar 2010

Keywords

  • Cisplatin
  • Estrogen receptor alpha
  • Estrogen receptor beta
  • Ovarian carcinoma
  • Tamoxifen

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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  • Cite this

    Ewa, N. M., Adam, M., Marek, P., Gansukh, T., Györffy, B., Marek, S., Maciej, Z., Manfred, D., Hermann, L., & Paweł, S. (2010). Wpływ tamoksifenu na platynowrażliwość i ekspresję receptorów estrogenowych linii komórkowych raka jajnika. Ginekologia Polska, 81(3), 183-187.