Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial

C. Bassi, D. D. Stocken, A. Oláh, H. Friess, J. Buckels, H. Hickey, C. Dervenis, J. A. Dunn, M. Deakin, R. Carter, P. Ghaneh, J. P. Neoptolemos, M. W. Büchler

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Abstract

Background/Aims: The influence of type of surgery and occurrence of post-operative complications on survival following adjuvant therapy for pancreatic cancer are uncertain. Methods: Cox proportional hazard modelling was used to investigate the influence of type of surgery and the presence of complications on survival in conjunction with clinico-pathological variables in the 550 patients of the ESPAC-1 adjuvant randomized controlled trial. Results: Standard Kausch-Whipple (KW) was performed in 282 (54%) patients, 186 (35%) had a pylorus-preserving (PP) KW, 39 (7%) had a distal pancreatectomy and 21 (4%) had a total pancreatectomy. Post-operative complications were reported in 140 (27%) patients. PP-KW patients survived longer with a median (95% CI) survival of 19.9 (17.3, 23.1) months compared to 14.8 (13.0, 16.7) for KW patients (χ 2 LR = 15.1, p <0.001). KW patients were more likely however to have R1 margins (67 (24%) vs. 29 (16%), χ 2 = 4.59, p = 0.032), poorly differentiated tumours (70 (26%) vs. 19 (10%), χ 2 = 18.65, p <0.001) and positive lymph nodes (165 (60%) vs. 81 (44%), χ 2 = 11.32, p <0.001). Post-operative complications did not significantly affect survival. Independent prognostic factors were tumour grade, nodal status and tumour size but not type of surgery or post-operative complications. There was a survival benefit for chemotherapy irrespective of the type of surgery or post-operative complications. Conclusions: The KW and PP-KW procedures did not significantly influence the hazard of death in the presence of tumour staging, demonstrating that ESPAC-1 surgeons showed good judgement in their choice of operation. Post-operative complications did not adversely affect the survival benefit from adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)353-363
Number of pages11
JournalDigestive Surgery
Volume22
Issue number5
DOIs
Publication statusPublished - 2005

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Pancreatic Neoplasms
Randomized Controlled Trials
Survival
Pylorus
Pancreatectomy
Therapeutics
Neoplasms
Neoplasm Staging
Adjuvant Chemotherapy
Lymph Nodes
Drug Therapy

Keywords

  • Cancer
  • Chemoradiotherapy
  • Chemotherapy
  • Pancreas
  • Pancreatic
  • Post-operative complications
  • Randomized controlled trial
  • Resection
  • Surgery

ASJC Scopus subject areas

  • Surgery

Cite this

Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial. / Bassi, C.; Stocken, D. D.; Oláh, A.; Friess, H.; Buckels, J.; Hickey, H.; Dervenis, C.; Dunn, J. A.; Deakin, M.; Carter, R.; Ghaneh, P.; Neoptolemos, J. P.; Büchler, M. W.

In: Digestive Surgery, Vol. 22, No. 5, 2005, p. 353-363.

Research output: Contribution to journalArticle

Bassi, C, Stocken, DD, Oláh, A, Friess, H, Buckels, J, Hickey, H, Dervenis, C, Dunn, JA, Deakin, M, Carter, R, Ghaneh, P, Neoptolemos, JP & Büchler, MW 2005, 'Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial', Digestive Surgery, vol. 22, no. 5, pp. 353-363. https://doi.org/10.1159/000089771
Bassi, C. ; Stocken, D. D. ; Oláh, A. ; Friess, H. ; Buckels, J. ; Hickey, H. ; Dervenis, C. ; Dunn, J. A. ; Deakin, M. ; Carter, R. ; Ghaneh, P. ; Neoptolemos, J. P. ; Büchler, M. W. / Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial. In: Digestive Surgery. 2005 ; Vol. 22, No. 5. pp. 353-363.
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abstract = "Background/Aims: The influence of type of surgery and occurrence of post-operative complications on survival following adjuvant therapy for pancreatic cancer are uncertain. Methods: Cox proportional hazard modelling was used to investigate the influence of type of surgery and the presence of complications on survival in conjunction with clinico-pathological variables in the 550 patients of the ESPAC-1 adjuvant randomized controlled trial. Results: Standard Kausch-Whipple (KW) was performed in 282 (54{\%}) patients, 186 (35{\%}) had a pylorus-preserving (PP) KW, 39 (7{\%}) had a distal pancreatectomy and 21 (4{\%}) had a total pancreatectomy. Post-operative complications were reported in 140 (27{\%}) patients. PP-KW patients survived longer with a median (95{\%} CI) survival of 19.9 (17.3, 23.1) months compared to 14.8 (13.0, 16.7) for KW patients (χ 2 LR = 15.1, p <0.001). KW patients were more likely however to have R1 margins (67 (24{\%}) vs. 29 (16{\%}), χ 2 = 4.59, p = 0.032), poorly differentiated tumours (70 (26{\%}) vs. 19 (10{\%}), χ 2 = 18.65, p <0.001) and positive lymph nodes (165 (60{\%}) vs. 81 (44{\%}), χ 2 = 11.32, p <0.001). Post-operative complications did not significantly affect survival. Independent prognostic factors were tumour grade, nodal status and tumour size but not type of surgery or post-operative complications. There was a survival benefit for chemotherapy irrespective of the type of surgery or post-operative complications. Conclusions: The KW and PP-KW procedures did not significantly influence the hazard of death in the presence of tumour staging, demonstrating that ESPAC-1 surgeons showed good judgement in their choice of operation. Post-operative complications did not adversely affect the survival benefit from adjuvant chemotherapy.",
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T1 - Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial

AU - Bassi, C.

AU - Stocken, D. D.

AU - Oláh, A.

AU - Friess, H.

AU - Buckels, J.

AU - Hickey, H.

AU - Dervenis, C.

AU - Dunn, J. A.

AU - Deakin, M.

AU - Carter, R.

AU - Ghaneh, P.

AU - Neoptolemos, J. P.

AU - Büchler, M. W.

PY - 2005

Y1 - 2005

N2 - Background/Aims: The influence of type of surgery and occurrence of post-operative complications on survival following adjuvant therapy for pancreatic cancer are uncertain. Methods: Cox proportional hazard modelling was used to investigate the influence of type of surgery and the presence of complications on survival in conjunction with clinico-pathological variables in the 550 patients of the ESPAC-1 adjuvant randomized controlled trial. Results: Standard Kausch-Whipple (KW) was performed in 282 (54%) patients, 186 (35%) had a pylorus-preserving (PP) KW, 39 (7%) had a distal pancreatectomy and 21 (4%) had a total pancreatectomy. Post-operative complications were reported in 140 (27%) patients. PP-KW patients survived longer with a median (95% CI) survival of 19.9 (17.3, 23.1) months compared to 14.8 (13.0, 16.7) for KW patients (χ 2 LR = 15.1, p <0.001). KW patients were more likely however to have R1 margins (67 (24%) vs. 29 (16%), χ 2 = 4.59, p = 0.032), poorly differentiated tumours (70 (26%) vs. 19 (10%), χ 2 = 18.65, p <0.001) and positive lymph nodes (165 (60%) vs. 81 (44%), χ 2 = 11.32, p <0.001). Post-operative complications did not significantly affect survival. Independent prognostic factors were tumour grade, nodal status and tumour size but not type of surgery or post-operative complications. There was a survival benefit for chemotherapy irrespective of the type of surgery or post-operative complications. Conclusions: The KW and PP-KW procedures did not significantly influence the hazard of death in the presence of tumour staging, demonstrating that ESPAC-1 surgeons showed good judgement in their choice of operation. Post-operative complications did not adversely affect the survival benefit from adjuvant chemotherapy.

AB - Background/Aims: The influence of type of surgery and occurrence of post-operative complications on survival following adjuvant therapy for pancreatic cancer are uncertain. Methods: Cox proportional hazard modelling was used to investigate the influence of type of surgery and the presence of complications on survival in conjunction with clinico-pathological variables in the 550 patients of the ESPAC-1 adjuvant randomized controlled trial. Results: Standard Kausch-Whipple (KW) was performed in 282 (54%) patients, 186 (35%) had a pylorus-preserving (PP) KW, 39 (7%) had a distal pancreatectomy and 21 (4%) had a total pancreatectomy. Post-operative complications were reported in 140 (27%) patients. PP-KW patients survived longer with a median (95% CI) survival of 19.9 (17.3, 23.1) months compared to 14.8 (13.0, 16.7) for KW patients (χ 2 LR = 15.1, p <0.001). KW patients were more likely however to have R1 margins (67 (24%) vs. 29 (16%), χ 2 = 4.59, p = 0.032), poorly differentiated tumours (70 (26%) vs. 19 (10%), χ 2 = 18.65, p <0.001) and positive lymph nodes (165 (60%) vs. 81 (44%), χ 2 = 11.32, p <0.001). Post-operative complications did not significantly affect survival. Independent prognostic factors were tumour grade, nodal status and tumour size but not type of surgery or post-operative complications. There was a survival benefit for chemotherapy irrespective of the type of surgery or post-operative complications. Conclusions: The KW and PP-KW procedures did not significantly influence the hazard of death in the presence of tumour staging, demonstrating that ESPAC-1 surgeons showed good judgement in their choice of operation. Post-operative complications did not adversely affect the survival benefit from adjuvant chemotherapy.

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KW - Chemoradiotherapy

KW - Chemotherapy

KW - Pancreas

KW - Pancreatic

KW - Post-operative complications

KW - Randomized controlled trial

KW - Resection

KW - Surgery

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