Influence of reaction-induced convection on quorum sensing in enzyme-loaded agarose beads

Vladimir M. Markovic, T. Bánsági, Dennel McKenzie, Anthony Mai, John A. Pojman, Annette F. Taylor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In theory, groups of enzyme-loaded particles producing an acid or base may show complex behavior including dynamical quorum sensing, the appearance of synchronized oscillations above a critical number or density of particles. Here, experiments were performed with the enzyme urease loaded into mm-sized agarose beads and placed in a solution of urea, resulting in an increase in pH. This behavior was found to be dependent upon the number of beads present in the array; however, reaction-induced convection occurred and plumes of high pH developed that extended to the walls of the reactor. The convection resulted in the motion of the mm-sized particles and conversion of the solution to high pH. Simulations in a simple model of the beads demonstrated the suppression of dynamical quorum sensing in the presence of flow.

Original languageEnglish
Article number033130
JournalChaos
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 1 2019

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Physics and Astronomy(all)
  • Applied Mathematics

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    Markovic, V. M., Bánsági, T., McKenzie, D., Mai, A., Pojman, J. A., & Taylor, A. F. (2019). Influence of reaction-induced convection on quorum sensing in enzyme-loaded agarose beads. Chaos, 29(3), [033130]. https://doi.org/10.1063/1.5089295