Az anyagok fizikai-kémiai tulajdonságainak befolyása a tabletták posztkompressziós paramétereire

Translated title of the contribution: Influence of physico-chemical properties of materials on the postcomprssional parameters of tablets

Tamás Sovány, Klára Hódi

Research output: Contribution to journalArticle

Abstract

The number of tablets marketed with a score line to aid divisibility is increasing. The subdivision of scored tablets in order to ensure dose flexibility may be an easier and cheaper solution from the aspect of production. However, to ensure the appropriate mechanical properties and divisibility of tablets so as to guarantee consequent dosing is a difficult problem, which is influenced by many properties of the applied materials, such as the physico-chemical behaviour, the plasticity, the degree of elasticity, the mechanism of compression, etc. These exert a significant influence on the postcompressional properties of tablets, and hence on the subdivision of tablets. Despite the considerable difficulties, the increasing importance in paediatrics and the ever stricter requirements of the drug authorities, the subdivision of scored tablets is a poorly studied field. This paper deals with the influence of physico-chemical properties of materials on the postcompressional parameters of tablets, and especially on the subdivision of tablets. For measurement of the force required to break tablets into halves, a laboratory-constructed hardness tester was utilized.

Original languageHungarian
Pages (from-to)123-130
Number of pages8
JournalActa pharmaceutica Hungarica
Volume84
Issue number4
Publication statusPublished - Jan 1 2014

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ASJC Scopus subject areas

  • Pharmaceutical Science

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