Influence of neonatal insulin imprinting on the insulin binding capacity of rat erythrocytes in adulthood.

G. Csaba, A. Inczefi-Gonda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A single neonatal insulin treatment decreased considerably the insulin binding capacity of erythrocytes in adult rats, by analogy of the behaviour of the hepatic insulin receptors in response to insulin exposure during the perinatal period, or during liver regeneration in adulthood. These observations substantitate earlier conclusions on the mechanism of imprinting and strongly suggest the universality of perinatal imprinting in living organisms. In vitro insulin exposure of the erythrocytes of adult rats depressed 48 h later the erythrocytic insulin binding capacity to a similar degree in individuals treated and not treated with insulin when newborn, from which it follows that neonatal exposure had no influence on erythrocytic response to later in vitro treatment. In the light of the present study the use of erythrocytes as model cells for imprinting studies deserves consideration.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalActa Physiologica Hungarica
Volume73
Issue number4
Publication statusPublished - 1989

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Erythrocytes
Insulin
Liver Regeneration
Insulin Receptor
Imprinting (Psychology)
Liver
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology

Cite this

Influence of neonatal insulin imprinting on the insulin binding capacity of rat erythrocytes in adulthood. / Csaba, G.; Inczefi-Gonda, A.

In: Acta Physiologica Hungarica, Vol. 73, No. 4, 1989, p. 483-487.

Research output: Contribution to journalArticle

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