Influence of kynurenine treatment on open-field activity, elevated plus-maze, avoidance behaviors and seizures in rats

László Vécsei, M. Flint Beal

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In the present studies the effects of single and daily repeated injections of kynurenine were investigated in different behavioral tests in rats. In open-field behavior a single injection of kynurenine decreased rearing activity, while the effect was more pronounced after repeated injections. Similarly, in the elevated plus-maze, kynurenine attenuated the total number of entries in the four arms of the equipment, and after chronic treatment decreased the time spent in the open arms (control: 24%; kynurenine 100 mg/kg: 16%; kynurenine 200 mg/kg: 13%). Kynurenine did not influence the passive avoidance learning paradigm (learning session and avoidance latency) and the extinction of active avoidance response. Kynurenine slightly attenuated the kainic acid-induced wet dog shakes and forelimb clonic activity with rearing. These findings suggest that kynurenine (especially after repeated peripheral injections) inhibited several behavioral responses of the experimental animals. However, in one type of highly motivated experimental paradigm (fear from the foot shock), behavioral depression was not detectable.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume37
Issue number1
DOIs
Publication statusPublished - Sep 1990

Keywords

  • Behavior
  • Kainic acid
  • Kynurenine
  • Rats

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Influence of kynurenine treatment on open-field activity, elevated plus-maze, avoidance behaviors and seizures in rats'. Together they form a unique fingerprint.

  • Cite this