Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy

Hansjürgen T. Agostini, Caroline F. Ryschkewitsch, Robert W. Baumhefner, Wallace W. Tourtellotto, Elyse J. Singer, S. Komoly, Gerald L. Stoner

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Two features of the biology of JC virus make it a particularly suitable candidate for an agent in MS-like disease: its neurotropic capability targeting glial cells as evidenced in progressive multifocal leukoencephalopathy lesions, and its capacity for latency and persistence as illustrated by its behaviour in the kidney. TC virus is chronically or intermittently excreted in the urine by some 40% of the population. The existence of TC virus in multiple coding-region genotypes provides a unique approach to the study of TC virus-induced neurological disease. We have previously shown that a genotype originating in Asia but also present in Europe and the US, called Type 2B, is more frequently found in PML brain than expected based on its prevalence in urine samples from a control population. In contrast, we find that the excretion of JCV in MS patients is similar in both genotype and frequency to that of control individuals, and appears to be regulated by factors unrelated to those that control CNS disease activity.

Original languageEnglish
JournalJournal of NeuroVirology
Volume6
Issue numberSUPPL. 2
Publication statusPublished - 2000

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JC Virus
Progressive Multifocal Leukoencephalopathy
Multiple Sclerosis
Genotype
Viruses
Urine
Central Nervous System Diseases
Neuroglia
Population
Kidney
Brain

Keywords

  • Demyelination
  • Genotype
  • Nuclear factor-1 site
  • Polyomavirus

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Agostini, H. T., Ryschkewitsch, C. F., Baumhefner, R. W., Tourtellotto, W. W., Singer, E. J., Komoly, S., & Stoner, G. L. (2000). Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy. Journal of NeuroVirology, 6(SUPPL. 2).

Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy. / Agostini, Hansjürgen T.; Ryschkewitsch, Caroline F.; Baumhefner, Robert W.; Tourtellotto, Wallace W.; Singer, Elyse J.; Komoly, S.; Stoner, Gerald L.

In: Journal of NeuroVirology, Vol. 6, No. SUPPL. 2, 2000.

Research output: Contribution to journalArticle

Agostini, HT, Ryschkewitsch, CF, Baumhefner, RW, Tourtellotto, WW, Singer, EJ, Komoly, S & Stoner, GL 2000, 'Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy', Journal of NeuroVirology, vol. 6, no. SUPPL. 2.
Agostini, Hansjürgen T. ; Ryschkewitsch, Caroline F. ; Baumhefner, Robert W. ; Tourtellotto, Wallace W. ; Singer, Elyse J. ; Komoly, S. ; Stoner, Gerald L. / Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy. In: Journal of NeuroVirology. 2000 ; Vol. 6, No. SUPPL. 2.
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