Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on bone health: Results from the european male ageing study

Stephen R. Pye, Bader Almusalam, Steven Boonen, Dirk Vanderschueren, Herman Borghs, Evelien Gielen, Judith E. Adams, Kate A. Ward, G. Bártfai, Felipe F. Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Fernand Labrie, Michael E J Lean, Neil Pendleton, Margus PunabAlan J. Silman, Frederick C W Wu, Terence W. O'Neill, Luisa Petrone, Giovanni Corona, Jolanta Slowikowska-Hilczer, Renata Walczak-Jedrzejowska, Ilpo Huhtaniemi, Frederick Wu, Alan Silman, Terence O'Neill, Joseph Finn, Philip Steer, Abdelouahid Tajar, David Lee, Stephen Pye, Felipe Casanueva, Mary Lage, Ana I. Castro, I. Földesi, I. Fejes, Paul Korrovitz, Min Jiang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study (EMAS). Subjects were invited by letter to complete a postal questionnaire and to attend for an interviewer-assisted questionnaire, quantitative ultrasound (QUS) of the calcaneus, and a fasting blood sample from which serum levels of IGFBP-1, IGFBP-3, IGF-I, estradiol (E2), and SHBG were assayed. The questionnaires included the Physical Activity Scale for the Elderly (PASE) and questions about smoking and alcohol consumption. Estimated bone mineral density (eBMD) was derived as a function of the QUS parameters speed of sound and broadband ultrasound attenuation. Height and weight were measured in all subjects. 3057 men, mean age 59.7 years (standard deviation 11.0) were included in the analysis. After adjusting for age, center, and BMI, higher levels of IGFBP-1 were associated with lower eBMD. Higher levels of both IGFBP-3 and IGF-I were associated with higher eBMD. After further adjustment for PASE score, current smoking, alcohol consumption, free E 2, and SHBG, IGFBP-3 and IGF-I, though not IGFBP-1, remained significantly associated with eBMD. IGFBP-1 was associated with bone health, though the effect could be explained by other factors. IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
JournalCalcified Tissue International
Volume88
Issue number6
DOIs
Publication statusPublished - 2011

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Bone Density
Bone and Bones
Health
Alcohol Drinking
Smoking
Exercise
Calcaneus
Registries
Estradiol
Fasting
Interviews
Weights and Measures
Serum
Surveys and Questionnaires

Keywords

  • Calcaneus quantitative ultrasound
  • Insulin-like growth factor binding protein 1
  • Insulin-like growth factor binding protein 3
  • Men
  • Population-based

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on bone health : Results from the european male ageing study. / Pye, Stephen R.; Almusalam, Bader; Boonen, Steven; Vanderschueren, Dirk; Borghs, Herman; Gielen, Evelien; Adams, Judith E.; Ward, Kate A.; Bártfai, G.; Casanueva, Felipe F.; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Labrie, Fernand; Lean, Michael E J; Pendleton, Neil; Punab, Margus; Silman, Alan J.; Wu, Frederick C W; O'Neill, Terence W.; Petrone, Luisa; Corona, Giovanni; Slowikowska-Hilczer, Jolanta; Walczak-Jedrzejowska, Renata; Huhtaniemi, Ilpo; Wu, Frederick; Silman, Alan; O'Neill, Terence; Finn, Joseph; Steer, Philip; Tajar, Abdelouahid; Lee, David; Pye, Stephen; Casanueva, Felipe; Lage, Mary; Castro, Ana I.; Földesi, I.; Fejes, I.; Korrovitz, Paul; Jiang, Min.

In: Calcified Tissue International, Vol. 88, No. 6, 2011, p. 503-510.

Research output: Contribution to journalArticle

Pye, SR, Almusalam, B, Boonen, S, Vanderschueren, D, Borghs, H, Gielen, E, Adams, JE, Ward, KA, Bártfai, G, Casanueva, FF, Finn, JD, Forti, G, Giwercman, A, Han, TS, Huhtaniemi, IT, Kula, K, Labrie, F, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ, Wu, FCW, O'Neill, TW, Petrone, L, Corona, G, Slowikowska-Hilczer, J, Walczak-Jedrzejowska, R, Huhtaniemi, I, Wu, F, Silman, A, O'Neill, T, Finn, J, Steer, P, Tajar, A, Lee, D, Pye, S, Casanueva, F, Lage, M, Castro, AI, Földesi, I, Fejes, I, Korrovitz, P & Jiang, M 2011, 'Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on bone health: Results from the european male ageing study', Calcified Tissue International, vol. 88, no. 6, pp. 503-510. https://doi.org/10.1007/s00223-011-9484-2
Pye, Stephen R. ; Almusalam, Bader ; Boonen, Steven ; Vanderschueren, Dirk ; Borghs, Herman ; Gielen, Evelien ; Adams, Judith E. ; Ward, Kate A. ; Bártfai, G. ; Casanueva, Felipe F. ; Finn, Joseph D. ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S. ; Huhtaniemi, Ilpo T. ; Kula, Krzysztof ; Labrie, Fernand ; Lean, Michael E J ; Pendleton, Neil ; Punab, Margus ; Silman, Alan J. ; Wu, Frederick C W ; O'Neill, Terence W. ; Petrone, Luisa ; Corona, Giovanni ; Slowikowska-Hilczer, Jolanta ; Walczak-Jedrzejowska, Renata ; Huhtaniemi, Ilpo ; Wu, Frederick ; Silman, Alan ; O'Neill, Terence ; Finn, Joseph ; Steer, Philip ; Tajar, Abdelouahid ; Lee, David ; Pye, Stephen ; Casanueva, Felipe ; Lage, Mary ; Castro, Ana I. ; Földesi, I. ; Fejes, I. ; Korrovitz, Paul ; Jiang, Min. / Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on bone health : Results from the european male ageing study. In: Calcified Tissue International. 2011 ; Vol. 88, No. 6. pp. 503-510.
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AU - Lean, Michael E J

AU - Pendleton, Neil

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AU - Wu, Frederick C W

AU - O'Neill, Terence W.

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AU - Corona, Giovanni

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AU - Walczak-Jedrzejowska, Renata

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AU - Finn, Joseph

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AU - Tajar, Abdelouahid

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KW - Insulin-like growth factor binding protein 3

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