Abstract
This pilot study was devoted to the effect of static magnetic field (SMF)-exposure on erosive gastritis. The randomized, self- and placebo-controlled, double-blind, pilot study included 16 patients of the 2nd Department of Internal Medicine, Semmelweis University diagnosed with erosive gastritis. The instrumental analysis followed a qualitative (pre-intervention) assessment of the symptoms by the patient: lower heartburn (in the ventricle), upper heartburn (in the oesophagus), epigastric pain, regurgitation, bloating and dry cough. Medical diagnosis included a double-line upper panendoscopy followed by 30 min local inhomogeneous SMF-exposure intervention at the lower sternal region over the stomach with peak-to-peak magnetic induction of 3 mT and 30 mT m-1 gradient at the target site. A qualitative (post-intervention) assessment of the same symptoms closed the examination. Sham- or SMF-exposure was used in a double-blind manner. The authors succeeded in justifying the clinically and statistically significant beneficial effect of the SMF- over sham-exposure on the symptoms of erosive gastritis, the average effect of inhibition was 56% by p = 0.001, n = 42 + 96. This pilot study was aimed to encourage gastroenterologists to test local, inhomogeneous SMF-exposure on erosive gastritis patients, so this intervention may become an evidence-based alternative or complementary method in the clinical use especially in cases when conventional therapy options are contraindicated.
Original language | English |
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Article number | 20140601 |
Journal | Journal of the Royal Society Interface |
Volume | 11 |
Issue number | 98 |
DOIs | |
Publication status | Published - Sep 6 2014 |
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Keywords
- Double-blind
- Erosive gastritis
- Pilot study
- Randomized
- Self- and placebo-controlled
- Static magnetic field-exposure
ASJC Scopus subject areas
- Biophysics
- Biotechnology
- Bioengineering
- Biomedical Engineering
- Biomaterials
- Biochemistry
- Medicine(all)
Cite this
Influence of inhomogeneous static magnetic field-exposure on patients with erosive gastritis : A randomized, self- and placebo-controlled, double-blind, single centre, pilot study. / Juhász, Márk; Nagy, Viktor L.; Székely, Hajnal; Kocsis, Dorottya; Tulassay, Z.; László, János F.
In: Journal of the Royal Society Interface, Vol. 11, No. 98, 20140601, 06.09.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of inhomogeneous static magnetic field-exposure on patients with erosive gastritis
T2 - A randomized, self- and placebo-controlled, double-blind, single centre, pilot study
AU - Juhász, Márk
AU - Nagy, Viktor L.
AU - Székely, Hajnal
AU - Kocsis, Dorottya
AU - Tulassay, Z.
AU - László, János F.
PY - 2014/9/6
Y1 - 2014/9/6
N2 - This pilot study was devoted to the effect of static magnetic field (SMF)-exposure on erosive gastritis. The randomized, self- and placebo-controlled, double-blind, pilot study included 16 patients of the 2nd Department of Internal Medicine, Semmelweis University diagnosed with erosive gastritis. The instrumental analysis followed a qualitative (pre-intervention) assessment of the symptoms by the patient: lower heartburn (in the ventricle), upper heartburn (in the oesophagus), epigastric pain, regurgitation, bloating and dry cough. Medical diagnosis included a double-line upper panendoscopy followed by 30 min local inhomogeneous SMF-exposure intervention at the lower sternal region over the stomach with peak-to-peak magnetic induction of 3 mT and 30 mT m-1 gradient at the target site. A qualitative (post-intervention) assessment of the same symptoms closed the examination. Sham- or SMF-exposure was used in a double-blind manner. The authors succeeded in justifying the clinically and statistically significant beneficial effect of the SMF- over sham-exposure on the symptoms of erosive gastritis, the average effect of inhibition was 56% by p = 0.001, n = 42 + 96. This pilot study was aimed to encourage gastroenterologists to test local, inhomogeneous SMF-exposure on erosive gastritis patients, so this intervention may become an evidence-based alternative or complementary method in the clinical use especially in cases when conventional therapy options are contraindicated.
AB - This pilot study was devoted to the effect of static magnetic field (SMF)-exposure on erosive gastritis. The randomized, self- and placebo-controlled, double-blind, pilot study included 16 patients of the 2nd Department of Internal Medicine, Semmelweis University diagnosed with erosive gastritis. The instrumental analysis followed a qualitative (pre-intervention) assessment of the symptoms by the patient: lower heartburn (in the ventricle), upper heartburn (in the oesophagus), epigastric pain, regurgitation, bloating and dry cough. Medical diagnosis included a double-line upper panendoscopy followed by 30 min local inhomogeneous SMF-exposure intervention at the lower sternal region over the stomach with peak-to-peak magnetic induction of 3 mT and 30 mT m-1 gradient at the target site. A qualitative (post-intervention) assessment of the same symptoms closed the examination. Sham- or SMF-exposure was used in a double-blind manner. The authors succeeded in justifying the clinically and statistically significant beneficial effect of the SMF- over sham-exposure on the symptoms of erosive gastritis, the average effect of inhibition was 56% by p = 0.001, n = 42 + 96. This pilot study was aimed to encourage gastroenterologists to test local, inhomogeneous SMF-exposure on erosive gastritis patients, so this intervention may become an evidence-based alternative or complementary method in the clinical use especially in cases when conventional therapy options are contraindicated.
KW - Double-blind
KW - Erosive gastritis
KW - Pilot study
KW - Randomized
KW - Self- and placebo-controlled
KW - Static magnetic field-exposure
UR - http://www.scopus.com/inward/record.url?scp=84904989248&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904989248&partnerID=8YFLogxK
U2 - 10.1098/rsif.2014.0601
DO - 10.1098/rsif.2014.0601
M3 - Article
C2 - 25008086
AN - SCOPUS:84904989248
VL - 11
JO - Journal of the Royal Society Interface
JF - Journal of the Royal Society Interface
SN - 1742-5689
IS - 98
M1 - 20140601
ER -