Účinok priemyselných minerálnych vláknitých prachov na parametre respiračnej toxicity - časová závislost

Translated title of the contribution: Influence of industrial mineral fiber dusts on respiration toxicity parameters - Time dependence

Hurbánková Marta, Černá Silvia, E. Tátrai, Barančoková Magdaléna, Kažimírová Alena, Volkovová Katarína, Staruchová Marta, Hrašková Dominika, Marcišiaková Jana, Wimmerová Soňa, Moricová Štefánia

Research output: Contribution to journalArticle

Abstract

The objective of the experimental investigation was to determine lung damage - respiratory toxicity - after exposure to selected industrial fiber dusts (glass fibers - GF, ceramic fibers - CF and amosite asbestos- AV as positive control) from the standpoint of time dependence. Animals were instilled with 4 mg glass fibers in 0,4 ml saline solution/animal, the control group with 0,4 ml saline solution. Wistar rats were sacrificed and bronchoalveolar lavage (BAL) were performed after instillation - 2, 30, 90 days. The authors examined selected inflammation, cytotoxic, immunotoxic, clastogenic, genotoxic parameters, the antioxidant state parameters and lung histology [number of BAL cells and alveolar macrophages (AM); differential picture of BAL cells (% AM, polymorphonuclear cells and lymphocytes), % of immature AM cells, multinuclear cells, viability and phygocytic activity of AM cells, frequency of micronuclei (MN), comet assay, FRA (ferric reducing ability) and histology of the lung tissue]. The influence of the industrial dusts under observation on the changes of lung tissue decreased in the following order: AMO > KV > SV. The course of time dependence curves of BAL parameters after exposure to all industrial fibers under investigation proved to be very similar. The explanation of their different consequences (finally the origin of disease) may be in their different biopersistence.

Original languageUndefined/Unknown
Pages (from-to)105-112
Number of pages8
JournalPracovni Lekarstvi
Volume65
Issue number3-4
Publication statusPublished - 2013

Fingerprint

Mineral Fibers
Alveolar Macrophages
Bronchoalveolar Lavage
Dust
Respiration
Alveolar Epithelial Cells
Lung
Sodium Chloride
Histology
Amosite Asbestos
Micronucleus Tests
Comet Assay
Ceramics
Wistar Rats
Cell Survival
Antioxidants
Lymphocytes
Inflammation
Control Groups
fiberglass

Keywords

  • Asbestos
  • Bronchoalveolar lavage
  • Ceramic and glass fibers
  • Clastogenic
  • Cytotoxic
  • Genotoxic parameters of antioxidant state and lung histology
  • Immunotoxic
  • Inflammation
  • Respiration toxicity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Marta, H., Silvia, Č., Tátrai, E., Magdaléna, B., Alena, K., Katarína, V., ... Štefánia, M. (2013). Účinok priemyselných minerálnych vláknitých prachov na parametre respiračnej toxicity - časová závislost. Pracovni Lekarstvi, 65(3-4), 105-112.

Účinok priemyselných minerálnych vláknitých prachov na parametre respiračnej toxicity - časová závislost. / Marta, Hurbánková; Silvia, Černá; Tátrai, E.; Magdaléna, Barančoková; Alena, Kažimírová; Katarína, Volkovová; Marta, Staruchová; Dominika, Hrašková; Jana, Marcišiaková; Soňa, Wimmerová; Štefánia, Moricová.

In: Pracovni Lekarstvi, Vol. 65, No. 3-4, 2013, p. 105-112.

Research output: Contribution to journalArticle

Marta, H, Silvia, Č, Tátrai, E, Magdaléna, B, Alena, K, Katarína, V, Marta, S, Dominika, H, Jana, M, Soňa, W & Štefánia, M 2013, 'Účinok priemyselných minerálnych vláknitých prachov na parametre respiračnej toxicity - časová závislost', Pracovni Lekarstvi, vol. 65, no. 3-4, pp. 105-112.
Marta, Hurbánková ; Silvia, Černá ; Tátrai, E. ; Magdaléna, Barančoková ; Alena, Kažimírová ; Katarína, Volkovová ; Marta, Staruchová ; Dominika, Hrašková ; Jana, Marcišiaková ; Soňa, Wimmerová ; Štefánia, Moricová. / Účinok priemyselných minerálnych vláknitých prachov na parametre respiračnej toxicity - časová závislost. In: Pracovni Lekarstvi. 2013 ; Vol. 65, No. 3-4. pp. 105-112.
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AU - Marta, Hurbánková

AU - Silvia, Černá

AU - Tátrai, E.

AU - Magdaléna, Barančoková

AU - Alena, Kažimírová

AU - Katarína, Volkovová

AU - Marta, Staruchová

AU - Dominika, Hrašková

AU - Jana, Marcišiaková

AU - Soňa, Wimmerová

AU - Štefánia, Moricová

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N2 - The objective of the experimental investigation was to determine lung damage - respiratory toxicity - after exposure to selected industrial fiber dusts (glass fibers - GF, ceramic fibers - CF and amosite asbestos- AV as positive control) from the standpoint of time dependence. Animals were instilled with 4 mg glass fibers in 0,4 ml saline solution/animal, the control group with 0,4 ml saline solution. Wistar rats were sacrificed and bronchoalveolar lavage (BAL) were performed after instillation - 2, 30, 90 days. The authors examined selected inflammation, cytotoxic, immunotoxic, clastogenic, genotoxic parameters, the antioxidant state parameters and lung histology [number of BAL cells and alveolar macrophages (AM); differential picture of BAL cells (% AM, polymorphonuclear cells and lymphocytes), % of immature AM cells, multinuclear cells, viability and phygocytic activity of AM cells, frequency of micronuclei (MN), comet assay, FRA (ferric reducing ability) and histology of the lung tissue]. The influence of the industrial dusts under observation on the changes of lung tissue decreased in the following order: AMO > KV > SV. The course of time dependence curves of BAL parameters after exposure to all industrial fibers under investigation proved to be very similar. The explanation of their different consequences (finally the origin of disease) may be in their different biopersistence.

AB - The objective of the experimental investigation was to determine lung damage - respiratory toxicity - after exposure to selected industrial fiber dusts (glass fibers - GF, ceramic fibers - CF and amosite asbestos- AV as positive control) from the standpoint of time dependence. Animals were instilled with 4 mg glass fibers in 0,4 ml saline solution/animal, the control group with 0,4 ml saline solution. Wistar rats were sacrificed and bronchoalveolar lavage (BAL) were performed after instillation - 2, 30, 90 days. The authors examined selected inflammation, cytotoxic, immunotoxic, clastogenic, genotoxic parameters, the antioxidant state parameters and lung histology [number of BAL cells and alveolar macrophages (AM); differential picture of BAL cells (% AM, polymorphonuclear cells and lymphocytes), % of immature AM cells, multinuclear cells, viability and phygocytic activity of AM cells, frequency of micronuclei (MN), comet assay, FRA (ferric reducing ability) and histology of the lung tissue]. The influence of the industrial dusts under observation on the changes of lung tissue decreased in the following order: AMO > KV > SV. The course of time dependence curves of BAL parameters after exposure to all industrial fibers under investigation proved to be very similar. The explanation of their different consequences (finally the origin of disease) may be in their different biopersistence.

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KW - Ceramic and glass fibers

KW - Clastogenic

KW - Cytotoxic

KW - Genotoxic parameters of antioxidant state and lung histology

KW - Immunotoxic

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