Influence of gonadotropin (FSH + LH) and thyrotropin (TSH) on the multiplication of chinese hamster ovary (CHO) cells. Impact of the age of the culture

G. Csaba, O. Török

Research output: Contribution to journalArticle

Abstract

CHO cells repeatedly treated with gonadotropin showed peak division rates after their third exposure and a decrease in the mitotic rate after their fourth exposure. Thyrotropin induced a considerable decrease in the mitotic rate following the first exposure, a significant increase after the second and a further decrease following the third and fourth exposures. The pattern did not differ between the two hormones when the cells were exposed further. The age (density of the cell cultures) had an appreciable influence on hormone-provoked changes in the mitotic rate, this differing only in intensity and never in the response following the initial re-exposure.

Original languageEnglish
Pages (from-to)639-643
Number of pages5
JournalCell Biology International Reports
Volume16
Issue number7
DOIs
Publication statusPublished - 1992

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Thyrotropin
Cricetulus
Gonadotropins
Ovary
Hormones
Cell Culture Techniques

ASJC Scopus subject areas

  • Cell Biology

Cite this

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abstract = "CHO cells repeatedly treated with gonadotropin showed peak division rates after their third exposure and a decrease in the mitotic rate after their fourth exposure. Thyrotropin induced a considerable decrease in the mitotic rate following the first exposure, a significant increase after the second and a further decrease following the third and fourth exposures. The pattern did not differ between the two hormones when the cells were exposed further. The age (density of the cell cultures) had an appreciable influence on hormone-provoked changes in the mitotic rate, this differing only in intensity and never in the response following the initial re-exposure.",
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AU - Török, O.

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AB - CHO cells repeatedly treated with gonadotropin showed peak division rates after their third exposure and a decrease in the mitotic rate after their fourth exposure. Thyrotropin induced a considerable decrease in the mitotic rate following the first exposure, a significant increase after the second and a further decrease following the third and fourth exposures. The pattern did not differ between the two hormones when the cells were exposed further. The age (density of the cell cultures) had an appreciable influence on hormone-provoked changes in the mitotic rate, this differing only in intensity and never in the response following the initial re-exposure.

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