Influence of flupirtine, a novel nonopioid analgesic agent on somatosensory evoked potentials in rats

L. Nagymajtényi, B. Nickel, I. Dési, I. Szelenyi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of flupirtine, a novel nonopioid analgesic, on somatosensory evoked potentials (SEP) was investigated in anesthetized rats. Primary somatosensory potentials were evoked in the cerebral cortex by stimulation of the skin of the whiskery part of the face. Flupirtine injected i.p. dose-dependently prolonged the latency and reduced the amplitude of SEP with ID50-values of 5.4 mg/kg (2.6-9.3 mg/kg) and 7.9 mg/kg (3.9-13.8 mg/kg), respectively. This effect of flupirtine (10 mg/kg, i.p.) on the latency and the amplitude of SEP, did not change when naloxone (1 mg/kg, i.p.) was given before flupirtine. The results indicate that the analgesic flupirtine decreases the primary somatosensory evoked potential by diminishing the excitability of cortical neurons. Opioid mechanisms are not involved.

Original languageEnglish
Pages (from-to)992-993
Number of pages2
JournalExperientia
Volume48
Issue number10
DOIs
Publication statusPublished - Oct 1992

Fingerprint

flupirtine
Non-Narcotic Analgesics
Somatosensory Evoked Potentials
Bioelectric potentials
Analgesics
Rats
Naloxone
Cerebral Cortex
Opioid Analgesics
Neurons
Skin

Keywords

  • Flupirtine
  • morphine
  • naloxone
  • rat
  • somatosensory evoked potential

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Influence of flupirtine, a novel nonopioid analgesic agent on somatosensory evoked potentials in rats. / Nagymajtényi, L.; Nickel, B.; Dési, I.; Szelenyi, I.

In: Experientia, Vol. 48, No. 10, 10.1992, p. 992-993.

Research output: Contribution to journalArticle

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