Diabetes mellitus hatása az agyi infarktusban szerepet játszó sejten belüli folyamatokra

Translated title of the contribution: Influence of diabetes mellitus on cerebral ischemia and reperfusion injury

Marianna Murányi, Z. Lacza

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cerebral ischemia, caused by disturbance of the bloo supply to the brain, is a major cause of death in our days. Diabetes mellitus exacerbates neuronal death induced by an ischemic insult. It is important to characterize the underlying mechanism of the cell damage in order to design therapeutic agents. The purpose of this study is to summarize some of the intracellular events leading to aggravated cell injury after diabetic ischemia including mitochondrial dysfunction. Release of mitochondrial cytochrome c activates the cell death executioner caspase-3 protease resulting in the cleavage of poly-ADP ribose polymerase (PARP) involved in DNA repair. Mitochondrial dysfunction is associated with enhanced production of free radicals such as superoxide anion, nitric oxide and peroxynitrite after diabetic ischemic injury. Mitochondrial dysfunction affects not only neurons but also astrocytes, which play an important role in neuronal functions. Damage of these cells participates in the exaggerated brain damage after cerebral ischemia. In summary, diabetes mellitus enhances intracellular pathways activated by cerebral ischemia and leads to exaggerated brain damage in diabetic subjects.

Original languageHungarian
Pages (from-to)1885-1889
Number of pages5
JournalOrvosi Hetilap
Volume147
Issue number39
Publication statusPublished - Oct 1 2006

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Reperfusion Injury
Brain Ischemia
Diabetes Mellitus
Brain
Peroxynitrous Acid
Poly(ADP-ribose) Polymerases
Wounds and Injuries
Cytochromes c
Superoxides
Caspase 3
Astrocytes
DNA Repair
Free Radicals
Cause of Death
Nitric Oxide
Peptide Hydrolases
Cell Death
Ischemia
Neurons
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diabetes mellitus hatása az agyi infarktusban szerepet játszó sejten belüli folyamatokra. / Murányi, Marianna; Lacza, Z.

In: Orvosi Hetilap, Vol. 147, No. 39, 01.10.2006, p. 1885-1889.

Research output: Contribution to journalArticle

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