Influence of cyclodextrins on the physical stability of DPPC-liposomes

I. Puskás, F. Csempesz

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This paper reports on the physical stability of DPPC-(dipalmitoyl phosphatidyl choline) liposomes in various aqueous dispersions and its control by uncharged polymers. The effect of natural (α-, β-, γ-) cyclodextrins (CDs) on the stability of bare and polymer-bearing liposomes and also, the attachment of the CD molecules and the macromolecules, respectively, to the DPPC-bilayers of small unilamellar vesicles (SUV) were studied. It was found that above a CD/DPPC ratio, each cyclodextrin caused a definite destruction in the phospholipid bilayers. The extent of membrane destabilization due to a cyclodextrin closely related to the amount of the CD molecules bound to the DPPC-bilayers. The polymer-coated liposomes formulated by incorporating a dissolved homopolymer or copolymer into the phospholipid bilayer of the vesicles exhibited higher physical stability. Uncharged polymers effectively hindered the disintegration of the liposomal membranes brought about by the CD molecules. The polymer layers formed around the phospholipid bilayers ensured an enhanced steric stabilization for the DPPC-liposomes. Methylcellulose (MC) with high molecular mass and a polyvinyl alcohol-co-vinyl propional copolymer alike exhibited efficient stabilizing effect.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume58
Issue number2
DOIs
Publication statusPublished - Aug 1 2007

Fingerprint

Liposomes
Cyclodextrins
Polymers
polymers
Phospholipids
vinyl copolymers
membranes
Molecules
molecules
choline
polyvinyl alcohol
Bearings (structural)
Copolymers
destabilization
disintegration
macromolecules
Membranes
Polyvinyl Alcohol
destruction
Unilamellar Liposomes

Keywords

  • Cyclodextrins
  • Dipalmitoyl phosphatidyl choline (DPPC)
  • Kinetic stability
  • Liposomes
  • Size distribution

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Influence of cyclodextrins on the physical stability of DPPC-liposomes. / Puskás, I.; Csempesz, F.

In: Colloids and Surfaces B: Biointerfaces, Vol. 58, No. 2, 01.08.2007, p. 218-224.

Research output: Contribution to journalArticle

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