Influence of cholecystokinin on the synaptosomal dopamine uptake in the nucleus accumbens of rats

László Hetey, Elena Döring, Botond Penke

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Abstract

The influence of the sulfated cholecystokinin octapeptide (CCK-8S) on the synaptosomal high-affinity [3H]dopamine (DA) uptake was investigated in the medial and lateral part of nucleus accumbens in rats. CCK-8S induced a concentration-dependent biphasic inhibition of [3H]-DA uptake in both subregions. After preincubation of CCK-8S with the synaptosomes the inhibitory effect was completely abolished. Kinetic analysis of the uptake influence suggests an uncompetitive inhibition by CCK-8S; this means that CCK-8S attacks only the DA-uptake carrier complex by inhibitory manner. The possible regulatory relevance of this mechanism is discussed.

Original languageEnglish
Pages (from-to)525-528
Number of pages4
JournalNeurochemistry international
Volume10
Issue number4
DOIs
Publication statusPublished - 1987

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ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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