Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMD a of the hip and spine in middle-aged and elderly European men

The European Male Ageing Study (EMAS)

Steven Boonen, Stephen R. Pye, Terence W. O'Neill, Pawel Szulc, Evelien Gielen, Herman Borghs, Sabine Verschueren, Frank Claessens, Judith E. Adams, Kate A. Ward, G. Bártfai, Felipe Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Fernand Labrie, Michael E J Lean & 25 others Neil Pendleton, Margus Punab, Alan J. Silman, Abdelouahid Tajar, Frederick C W Wu, Dirk Vanderschueren, F. C W Wu, Luisa Petrone, Giovanni Corona, Jolanta Slowikowska-Hilczer, Renata Walczak-Jedrzejowska, Ilpo Huhtaniemi, Frederick Wu, Alan Silman, Terence O'Neill, Joseph Finn, Philip Steer, David Lee, Stephen Pye, Mary Lage, Ana I. Castro, I. Földesi, I. Fejes, Paul Korrovitz, Min Jiang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β C-terminal cross-linked telopeptide (β-cTX)), total testosterone, total oestradiol (E 2), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dual-energy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: A total of 3120, mean age 59.9 years (S.D.=11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E 2 were negatively associated with β-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both β-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: E 2, SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health.

Original languageEnglish
Pages (from-to)977-986
Number of pages10
JournalEuropean Journal of Endocrinology
Volume165
Issue number6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Calcaneus
Bone Remodeling
Photon Absorptiometry
Hip
Spine
Sex Hormone-Binding Globulin
Bone and Bones
Somatomedins
Parathyroid Hormone
Testosterone
Life Style
Social Adjustment
Health
Gonadal Steroid Hormones
Collagen Type I
Bone Density
Registries
Estradiol
Fasting
Biomarkers

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMD a of the hip and spine in middle-aged and elderly European men : The European Male Ageing Study (EMAS). / Boonen, Steven; Pye, Stephen R.; O'Neill, Terence W.; Szulc, Pawel; Gielen, Evelien; Borghs, Herman; Verschueren, Sabine; Claessens, Frank; Adams, Judith E.; Ward, Kate A.; Bártfai, G.; Casanueva, Felipe; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Labrie, Fernand; Lean, Michael E J; Pendleton, Neil; Punab, Margus; Silman, Alan J.; Tajar, Abdelouahid; Wu, Frederick C W; Vanderschueren, Dirk; Wu, F. C W; Petrone, Luisa; Corona, Giovanni; Slowikowska-Hilczer, Jolanta; Walczak-Jedrzejowska, Renata; Huhtaniemi, Ilpo; Wu, Frederick; Silman, Alan; O'Neill, Terence; Finn, Joseph; Steer, Philip; Lee, David; Pye, Stephen; Lage, Mary; Castro, Ana I.; Földesi, I.; Fejes, I.; Korrovitz, Paul; Jiang, Min.

In: European Journal of Endocrinology, Vol. 165, No. 6, 12.2011, p. 977-986.

Research output: Contribution to journalArticle

Boonen, S, Pye, SR, O'Neill, TW, Szulc, P, Gielen, E, Borghs, H, Verschueren, S, Claessens, F, Adams, JE, Ward, KA, Bártfai, G, Casanueva, F, Finn, JD, Forti, G, Giwercman, A, Han, TS, Huhtaniemi, IT, Kula, K, Labrie, F, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ, Tajar, A, Wu, FCW, Vanderschueren, D, Wu, FCW, Petrone, L, Corona, G, Slowikowska-Hilczer, J, Walczak-Jedrzejowska, R, Huhtaniemi, I, Wu, F, Silman, A, O'Neill, T, Finn, J, Steer, P, Lee, D, Pye, S, Lage, M, Castro, AI, Földesi, I, Fejes, I, Korrovitz, P & Jiang, M 2011, 'Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMD a of the hip and spine in middle-aged and elderly European men: The European Male Ageing Study (EMAS)', European Journal of Endocrinology, vol. 165, no. 6, pp. 977-986. https://doi.org/10.1530/EJE-11-0353
Boonen, Steven ; Pye, Stephen R. ; O'Neill, Terence W. ; Szulc, Pawel ; Gielen, Evelien ; Borghs, Herman ; Verschueren, Sabine ; Claessens, Frank ; Adams, Judith E. ; Ward, Kate A. ; Bártfai, G. ; Casanueva, Felipe ; Finn, Joseph D. ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S. ; Huhtaniemi, Ilpo T. ; Kula, Krzysztof ; Labrie, Fernand ; Lean, Michael E J ; Pendleton, Neil ; Punab, Margus ; Silman, Alan J. ; Tajar, Abdelouahid ; Wu, Frederick C W ; Vanderschueren, Dirk ; Wu, F. C W ; Petrone, Luisa ; Corona, Giovanni ; Slowikowska-Hilczer, Jolanta ; Walczak-Jedrzejowska, Renata ; Huhtaniemi, Ilpo ; Wu, Frederick ; Silman, Alan ; O'Neill, Terence ; Finn, Joseph ; Steer, Philip ; Lee, David ; Pye, Stephen ; Lage, Mary ; Castro, Ana I. ; Földesi, I. ; Fejes, I. ; Korrovitz, Paul ; Jiang, Min. / Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMD a of the hip and spine in middle-aged and elderly European men : The European Male Ageing Study (EMAS). In: European Journal of Endocrinology. 2011 ; Vol. 165, No. 6. pp. 977-986.
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abstract = "Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β C-terminal cross-linked telopeptide (β-cTX)), total testosterone, total oestradiol (E 2), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dual-energy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: A total of 3120, mean age 59.9 years (S.D.=11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E 2 were negatively associated with β-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both β-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: E 2, SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health.",
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T1 - Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMD a of the hip and spine in middle-aged and elderly European men

T2 - The European Male Ageing Study (EMAS)

AU - Boonen, Steven

AU - Pye, Stephen R.

AU - O'Neill, Terence W.

AU - Szulc, Pawel

AU - Gielen, Evelien

AU - Borghs, Herman

AU - Verschueren, Sabine

AU - Claessens, Frank

AU - Adams, Judith E.

AU - Ward, Kate A.

AU - Bártfai, G.

AU - Casanueva, Felipe

AU - Finn, Joseph D.

AU - Forti, Gianni

AU - Giwercman, Aleksander

AU - Han, Thang S.

AU - Huhtaniemi, Ilpo T.

AU - Kula, Krzysztof

AU - Labrie, Fernand

AU - Lean, Michael E J

AU - Pendleton, Neil

AU - Punab, Margus

AU - Silman, Alan J.

AU - Tajar, Abdelouahid

AU - Wu, Frederick C W

AU - Vanderschueren, Dirk

AU - Wu, F. C W

AU - Petrone, Luisa

AU - Corona, Giovanni

AU - Slowikowska-Hilczer, Jolanta

AU - Walczak-Jedrzejowska, Renata

AU - Huhtaniemi, Ilpo

AU - Wu, Frederick

AU - Silman, Alan

AU - O'Neill, Terence

AU - Finn, Joseph

AU - Steer, Philip

AU - Lee, David

AU - Pye, Stephen

AU - Lage, Mary

AU - Castro, Ana I.

AU - Földesi, I.

AU - Fejes, I.

AU - Korrovitz, Paul

AU - Jiang, Min

PY - 2011/12

Y1 - 2011/12

N2 - Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β C-terminal cross-linked telopeptide (β-cTX)), total testosterone, total oestradiol (E 2), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dual-energy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: A total of 3120, mean age 59.9 years (S.D.=11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E 2 were negatively associated with β-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both β-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: E 2, SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health.

AB - Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β C-terminal cross-linked telopeptide (β-cTX)), total testosterone, total oestradiol (E 2), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dual-energy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: A total of 3120, mean age 59.9 years (S.D.=11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E 2 were negatively associated with β-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both β-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: E 2, SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health.

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