Influence of azathioprine treatment on the outcome of experimental kidney transplantations

B. Török, I. Tóth, F. Götz, E. Róth, G. Temes, L. Váry, T. Szmolenszky, F. Balogh, G. Romhányi

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Abstract

Kidney homotransplantations were performed in dogs after bilateral nephrectomy. Azathioprine (Imuran) was given in daily doses of 5 mg/kg as the only therapy, so as to assess its influence on homograft retention. The average survival of the animals was 24.66 days, i.e. slightly longer than in the controls (18.2 days). Light and polarization microscopy revealed that azathioprine had affected neither the early nor the late phase of homograft reaction, except for a slight delay in the start of the rejection process and its focal character. The subsequent course of the reaction proceeded unhindered.

Original languageEnglish
Pages (from-to)143-156
Number of pages14
JournalInternational urology and nephrology
Volume2
Issue number2
DOIs
Publication statusPublished - Jun 1 1970

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ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Török, B., Tóth, I., Götz, F., Róth, E., Temes, G., Váry, L., Szmolenszky, T., Balogh, F., & Romhányi, G. (1970). Influence of azathioprine treatment on the outcome of experimental kidney transplantations. International urology and nephrology, 2(2), 143-156. https://doi.org/10.1007/BF02125815