Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension

A follow-up study

Enikő Csikai, Mónika Andrejkovics, Bernadett Balajthy-Hidegh, Gergely Hofgárt, László Kardos, Ágnes Diószegi, Róbert Rostás, Katalin Réka Czuriga-Kovács, Éva Csongrádi, L. Csiba

Research output: Contribution to journalArticle

Abstract

The importance of optimal blood pressure control for preventing or reducing the impairment of vascular and cognitive functions is well known. However, the reversibility of early alterations in vascular and cognitive functions through antihypertensive agents is under-investigated. In this study, we evaluated the influence of 3 months of angiotensin-converting enzyme (ACE) inhibition treatment on the morphological and functional arterial wall and cognitive performance changes in 30 newly diagnosed primary hypertensive patients.Common carotid intima-media thickness (IMT) and brachial artery flow-mediated dilatation (FMD) were detected by ultrasonography. Arterial stiffness indicated by augmentation index (AIx) and pulse wave velocity (PWV) was assessed by arteriography. Cognitive functions were assessed by neuropsychological examination.The executive function overall score was significantly higher at 3-month follow-up than at baseline (median, 0.233 (IQR, 0.447) vs -0.038 (0.936); P = .001). Three-month ACE inhibition did not produce significant improvement in IMT, FMD, AIx and PWV values. Significant negative associations were revealed between IMT and complex attention (r = -0.598, P = .0008), executive function (r = -0.617, P = .0005), and immediate memory (r = -0.420, P = .026) overall scores at follow-up. AIx had significant negative correlations with complex attention (r = -0.568, P = .001), executive function (r = -0.374, P = .046), and immediate memory (r = -0.507, P = .005). PWV correlated significantly and negatively with complex attention (r = -0.490, P = .007).Timely and effective antihypertensive therapy with ACE inhibitors has significant beneficial effects on cognitive performance in as few as 3 months. Early ACE inhibition may have an important role in the reversal of initial impairments of cognitive function associated with hypertension-induced vascular alterations.

Original languageEnglish
Pages (from-to)e16966
JournalMedicine
Volume98
Issue number34
DOIs
Publication statusPublished - Aug 1 2019

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Peptidyl-Dipeptidase A
Cognition
Pulse Wave Analysis
Executive Function
Hypertension
Blood Vessels
Short-Term Memory
Antihypertensive Agents
Dilatation
Carotid Intima-Media Thickness
Vascular Stiffness
Brachial Artery
Angiotensin-Converting Enzyme Inhibitors
Ultrasonography
Angiography
Blood Pressure
Inhibition (Psychology)
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension : A follow-up study. / Csikai, Enikő; Andrejkovics, Mónika; Balajthy-Hidegh, Bernadett; Hofgárt, Gergely; Kardos, László; Diószegi, Ágnes; Rostás, Róbert; Czuriga-Kovács, Katalin Réka; Csongrádi, Éva; Csiba, L.

In: Medicine, Vol. 98, No. 34, 01.08.2019, p. e16966.

Research output: Contribution to journalArticle

Csikai, E, Andrejkovics, M, Balajthy-Hidegh, B, Hofgárt, G, Kardos, L, Diószegi, Á, Rostás, R, Czuriga-Kovács, KR, Csongrádi, É & Csiba, L 2019, 'Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension: A follow-up study', Medicine, vol. 98, no. 34, pp. e16966. https://doi.org/10.1097/MD.0000000000016966
Csikai, Enikő ; Andrejkovics, Mónika ; Balajthy-Hidegh, Bernadett ; Hofgárt, Gergely ; Kardos, László ; Diószegi, Ágnes ; Rostás, Róbert ; Czuriga-Kovács, Katalin Réka ; Csongrádi, Éva ; Csiba, L. / Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension : A follow-up study. In: Medicine. 2019 ; Vol. 98, No. 34. pp. e16966.
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