Influence of anesthetics on the incidence of reperfusion-induced arrhythmias and sudden death in rats

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21 Citations (Scopus)

Abstract

Purpose: We compared the influence of pentobarbital (P, 60 mg/kg), urethane (U, 1.8 g/kg), and a contribution of diazepam with ketamine hydrochloride (D+K, 10 + 100 mg/kg) anesthesia on the incidence of ischemia/reperfusion induced arrhythmias in rats. In anesthetized rats, myocardial ischemia was produced by a 6-min ligation of the left main coronary artery, followed by 5 min of reperfusion. The incidence of reperfusion-induced ventricular fibrillation (VF) and ventricular tachycardia (VT) was markedly decreased in the D+K-anesthetized animals compared with the P-anesthetized group (VF, 46 vs. 89%: VT, 64 vs. 94%). The mean blood pressure (MBP) before coronary ligation was significantly lower in U-anesthetized animals (72 ± 3.5 vs. 102 ± 4.1 and 108 + 5.9 mm Hg in P and D+K, respectively). The MBP recovery was the best in the D+K- anesthetized group. In experimental work, pentobarbitone anesthesia may be recommended for studying arrhythmias, while the combination of diazepam and ketamine may be useful for hemodynamic investigations.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalJournal of cardiovascular pharmacology
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 1 1997

Keywords

  • Diazepam
  • Ketamine
  • Pentobarbitone
  • Rats
  • Reperfusion arrhythmias
  • Urethane

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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