Influence of age on the signal transduction of T cells in mice

Masanori Utsuyama, Z. Varga, Kiyoko Fukami, Yoshimi Homma, Tadaomi Takenawa, Katsuiku Hirokawa

Research output: Contribution to journalArticle

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Abstract

A 5- to 10-fold decline was observed in the proliferative activity of T cells stimulated with anti- CD3 mAb between young and old mice. However, the number of CD3 molecules on the T cell surface was almost comparable between young and old T cells. The formation of the second messenger such as inositol triphosphate (IP3) and dlacylglycerol (DAG) after mitogenic stimulation decreased in old T cells as compared with young ones. The activity of phospholipase C (PLC), which is responsible for the liberation of IP3 and DAG from phosphatidylinositol-4, 5- blsphosphate (PIP2 was not different between young and old T cells. The content of PIP2 in the membrane was also comparable between young and old T cells. These findings have suggested that the age-related decline in the prollferative activity of T cells could be due to impairment of intracellular signal transduction, probably in the pathway somewhere between TCR and PLC.

Original languageEnglish
Pages (from-to)1177-1182
Number of pages6
JournalInternational Immunology
Volume5
Issue number9
DOIs
Publication statusPublished - Sep 1993

Fingerprint

Signal transduction
T-cells
Signal Transduction
Mouse
T-Lymphocytes
Type C Phospholipases
Second Messenger
Second Messenger Systems
Inositol
Phosphatidylinositols
Influence
Pathway
Fold
Membrane
Molecules
Membranes

Keywords

  • Diacylgylcerol
  • Inositol phosphates
  • Phospholipase C
  • Second messengers

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Transplantation
  • Immunology

Cite this

Utsuyama, M., Varga, Z., Fukami, K., Homma, Y., Takenawa, T., & Hirokawa, K. (1993). Influence of age on the signal transduction of T cells in mice. International Immunology, 5(9), 1177-1182. https://doi.org/10.1093/intimm/5.9.1177

Influence of age on the signal transduction of T cells in mice. / Utsuyama, Masanori; Varga, Z.; Fukami, Kiyoko; Homma, Yoshimi; Takenawa, Tadaomi; Hirokawa, Katsuiku.

In: International Immunology, Vol. 5, No. 9, 09.1993, p. 1177-1182.

Research output: Contribution to journalArticle

Utsuyama, M, Varga, Z, Fukami, K, Homma, Y, Takenawa, T & Hirokawa, K 1993, 'Influence of age on the signal transduction of T cells in mice', International Immunology, vol. 5, no. 9, pp. 1177-1182. https://doi.org/10.1093/intimm/5.9.1177
Utsuyama, Masanori ; Varga, Z. ; Fukami, Kiyoko ; Homma, Yoshimi ; Takenawa, Tadaomi ; Hirokawa, Katsuiku. / Influence of age on the signal transduction of T cells in mice. In: International Immunology. 1993 ; Vol. 5, No. 9. pp. 1177-1182.
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