Influence of acetone on the hepatotoxicity of methylglyoxal

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Abstract

We have examined the effects of acetone, dimethyl sulfoxide and ethanol on hepatotoxicity provoked by methylglyoxal in mice. The actions of acetone and ethanol were synergistic with that of methylglyoxal in terms of glutathione depletion, increased microsomal aniline hydroxylase and serum glutamate pyruvate transaminase activities, and histomorphological changes in the centrolobular region of liver specimens. The most characteristic morphological observation in the livers of methylglyoxal-treated animals was vacuole formation in the hepatocytes. In each of these cases dimethyl sulfoxide exerted a protective effect against methylglyoxal toxicity. The possible pathological role of methylglyoxal in microtubular assembly is discussed. It is concluded that its acute toxicity is due to its direct interaction with macromolecules rather than to the depletion of glutathione stores.

Original languageEnglish
Pages (from-to)617-620
Number of pages4
JournalMedical Science Research
Volume27
Issue number9
Publication statusPublished - Dec 1 1999

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Keywords

  • Acetone
  • Centrolobular damage
  • Dimethyl sulfoxide
  • Liver
  • Methylglyoxal

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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