Influence of [4Cl-D-Phe6,Leu17]VIP on VIP- and central TRH-induced gastric hyperemia

Ágnes Király, Gábor Sütó, Paul Guth, Yvette Taché

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The specific VIP receptor antagonist, [4Cl-D-Phe6,Leu17]VIP, infused iv blocked close-intra-arterial infusion of VIP-induced increase in gastric mucosal blood flow (GMBP, measured by the hydrogen gas clearance), and decrease in mean arterial blood pressure while not influencing basal levels in urethane-anesthetized rats. The thyrotropin-releasing hormone (TRH) stable analog, RX 77368, injected intracisternally (IC, 30 ng) increased GMBF and blood pressure. The VIP antagonist did not significantly reduce the GMBF response to IC RX 77368 while enhancing the rise in blood pressure. These findings indicate that [4Cl-D-Phe6,Leu17]VIP is an antagonist for exogenous VIP-induced gastric hyperemia and hypotension and that VIP modulates the systemic blood pressure response to IC RX 77368 at 30 ng while not playing a primary role in the increase of GMBF.

Original languageEnglish
Pages (from-to)1321-1325
Number of pages5
JournalPeptides
Volume18
Issue number9
DOIs
Publication statusPublished - Dec 17 1997

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Keywords

  • Blood pressure
  • Gastric mucosal blood flow
  • Gastric vascular resistance
  • RX 77368
  • TRH analog
  • VIP
  • VIP antagonist
  • Vagus

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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