Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia

Ezra Mulugeta, Francisco Molina-Holgado, Mark S. Elliott, T. Hortobágyi, Robert Perry, Rajesh N. Kalaria, Clive G. Ballard, Paul T. Francis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Vascular dementia (VaD) accounts for about 20% of all dementias, and vascular risk is a key factor in more than 40% of people with Alzheimer's disease (AD). Little is known about inflammatory processes in the brains of these individuals. We have examined inflammatory mediators (interleukin (IL)-1β, IL-1α, IL-6 and tumour necrosis factor α) and chemokines (macrophage inflammatory protein 1, monocyte chemo-attractant protein (MCP)-1 and granulocyte macrophage colony-stimulating factor) in brain homogenates from grey and white matter of the frontal cortex (Brodmann area 9) from patients with VaD (n = 11), those with concurrent VaD and AD (mixed dementia; n = 8) and from age-matched controls (n = 13) using ELISA assays. We found a dramatic reduction of MCP-1 levels in the grey matter in VaD and mixed dementia in comparison to controls (55 and 66%, respectively). IL-6 decreases were also observed in the grey matter of VaD and mixed dementia (72 and 71%, respectively), with a more modest decrease (30%) in the white matter of patients with VaD or mixed dementia. In the first study to examine the status of inflammatory mediators in a brain region severely affected by white-matter lesions, our findings highlight - in contrast to previous reports in AD - that patients at the later stage of VaD or mixed dementia have a significantly attenuated neuro-inflammatory response.

Original languageEnglish
Pages (from-to)278-286
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Vascular Dementia
Frontal Lobe
Dementia
Alzheimer Disease
Interleukin-1
Monocytes
Interleukin-6
Brain
Macrophage Inflammatory Proteins
Granulocyte-Macrophage Colony-Stimulating Factor
Vascular Diseases
Chemokines
Proteins
Tumor Necrosis Factor-alpha
Enzyme-Linked Immunosorbent Assay

Keywords

  • Alzheimer's disease
  • Mixed dementia
  • Pro-inflammatory and anti-inflammatory cytokines
  • Vascular dementia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Mulugeta, E., Molina-Holgado, F., Elliott, M. S., Hortobágyi, T., Perry, R., Kalaria, R. N., ... Francis, P. T. (2008). Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia. Dementia and Geriatric Cognitive Disorders, 25(3), 278-286. https://doi.org/10.1159/000118633

Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia. / Mulugeta, Ezra; Molina-Holgado, Francisco; Elliott, Mark S.; Hortobágyi, T.; Perry, Robert; Kalaria, Rajesh N.; Ballard, Clive G.; Francis, Paul T.

In: Dementia and Geriatric Cognitive Disorders, Vol. 25, No. 3, 03.2008, p. 278-286.

Research output: Contribution to journalArticle

Mulugeta, E, Molina-Holgado, F, Elliott, MS, Hortobágyi, T, Perry, R, Kalaria, RN, Ballard, CG & Francis, PT 2008, 'Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia', Dementia and Geriatric Cognitive Disorders, vol. 25, no. 3, pp. 278-286. https://doi.org/10.1159/000118633
Mulugeta, Ezra ; Molina-Holgado, Francisco ; Elliott, Mark S. ; Hortobágyi, T. ; Perry, Robert ; Kalaria, Rajesh N. ; Ballard, Clive G. ; Francis, Paul T. / Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia. In: Dementia and Geriatric Cognitive Disorders. 2008 ; Vol. 25, No. 3. pp. 278-286.
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