Inflammatory bowel disease course in Crohn's disease

Is the natural history changing?

Petra A. Golovics, Michael D. Mandel, Barbara D. Lovasz, P. Lakatos

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Crohn's disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability. Studies on the natural history of CD provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. Most data are available from referral centers, however these outcomes may be different from those in population-based cohorts. New data suggest the possibility of a change in the natural history in Crohn's disease, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to have decreased in the last decade. In addition, mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive. In this review article, the authors summarize the available evidence on the natural history, current trends, and predictive factors for evaluating the disease course of CD.

Original languageEnglish
Pages (from-to)3198-3207
Number of pages10
JournalWorld Journal of Gastroenterology
Volume20
Issue number12
DOIs
Publication statusPublished - 2014

Fingerprint

Natural History
Inflammatory Bowel Diseases
Crohn Disease
Biological Therapy
Environmental Monitoring
Physiologic Monitoring
Immunosuppressive Agents
Population
Hospitalization
Referral and Consultation
Phenotype
Mortality
Therapeutics

Keywords

  • Crohn's disease
  • Disease course
  • Inflammatory bowel disease
  • Mortality
  • Natural history
  • Surgery

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Inflammatory bowel disease course in Crohn's disease : Is the natural history changing? / Golovics, Petra A.; Mandel, Michael D.; Lovasz, Barbara D.; Lakatos, P.

In: World Journal of Gastroenterology, Vol. 20, No. 12, 2014, p. 3198-3207.

Research output: Contribution to journalArticle

Golovics, Petra A. ; Mandel, Michael D. ; Lovasz, Barbara D. ; Lakatos, P. / Inflammatory bowel disease course in Crohn's disease : Is the natural history changing?. In: World Journal of Gastroenterology. 2014 ; Vol. 20, No. 12. pp. 3198-3207.
@article{5862f898463a4d19a99200514d2ff0af,
title = "Inflammatory bowel disease course in Crohn's disease: Is the natural history changing?",
abstract = "Crohn's disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability. Studies on the natural history of CD provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. Most data are available from referral centers, however these outcomes may be different from those in population-based cohorts. New data suggest the possibility of a change in the natural history in Crohn's disease, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to have decreased in the last decade. In addition, mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive. In this review article, the authors summarize the available evidence on the natural history, current trends, and predictive factors for evaluating the disease course of CD.",
keywords = "Crohn's disease, Disease course, Inflammatory bowel disease, Mortality, Natural history, Surgery",
author = "Golovics, {Petra A.} and Mandel, {Michael D.} and Lovasz, {Barbara D.} and P. Lakatos",
year = "2014",
doi = "10.3748/wjg.v20.i12.3198",
language = "English",
volume = "20",
pages = "3198--3207",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "12",

}

TY - JOUR

T1 - Inflammatory bowel disease course in Crohn's disease

T2 - Is the natural history changing?

AU - Golovics, Petra A.

AU - Mandel, Michael D.

AU - Lovasz, Barbara D.

AU - Lakatos, P.

PY - 2014

Y1 - 2014

N2 - Crohn's disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability. Studies on the natural history of CD provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. Most data are available from referral centers, however these outcomes may be different from those in population-based cohorts. New data suggest the possibility of a change in the natural history in Crohn's disease, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to have decreased in the last decade. In addition, mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive. In this review article, the authors summarize the available evidence on the natural history, current trends, and predictive factors for evaluating the disease course of CD.

AB - Crohn's disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability. Studies on the natural history of CD provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. Most data are available from referral centers, however these outcomes may be different from those in population-based cohorts. New data suggest the possibility of a change in the natural history in Crohn's disease, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to have decreased in the last decade. In addition, mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive. In this review article, the authors summarize the available evidence on the natural history, current trends, and predictive factors for evaluating the disease course of CD.

KW - Crohn's disease

KW - Disease course

KW - Inflammatory bowel disease

KW - Mortality

KW - Natural history

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=84896977224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896977224&partnerID=8YFLogxK

U2 - 10.3748/wjg.v20.i12.3198

DO - 10.3748/wjg.v20.i12.3198

M3 - Article

VL - 20

SP - 3198

EP - 3207

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 12

ER -