Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.

Original languageEnglish
Pages (from-to)240-242
Number of pages3
JournalAgents and Actions
Volume25
Issue number3-4
DOIs
Publication statusPublished - Sep 1988

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Spinal Nerve Roots
Neurons
Rats
Skin
Anti-Inflammatory Agents
Chemical activation
Plasmas
Afferent Neurons

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat. / Pintér, E.; Szolcsányi, J.

In: Agents and Actions, Vol. 25, No. 3-4, 09.1988, p. 240-242.

Research output: Contribution to journalArticle

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