Abstract
Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 240-242 |
| Number of pages | 3 |
| Journal | Agents and Actions |
| Volume | 25 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Sep 1988 |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)
Cite this
Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat. / Pintér, E.; Szolcsányi, J.
In: Agents and Actions, Vol. 25, No. 3-4, 09.1988, p. 240-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat
AU - Pintér, E.
AU - Szolcsányi, J.
PY - 1988/9
Y1 - 1988/9
N2 - Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.
AB - Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.
UR - http://www.scopus.com/inward/record.url?scp=0024226902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024226902&partnerID=8YFLogxK
U2 - 10.1007/BF01965023
DO - 10.1007/BF01965023
M3 - Article
C2 - 3218602
AN - SCOPUS:0024226902
VL - 25
SP - 240
EP - 242
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - 3-4
ER -