Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat

E. Pintér; J. Szolcsànyi

doi:10.1007/BF01965023

Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat

E. Pintér, J. Szolcsànyi

University of Pécs

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.

Original language	English
Pages (from-to)	240-242
Number of pages	3
Journal	Agents and Actions
Volume	25
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01965023
Publication status	Published - Sep 1 1988

Fingerprint

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

Cite this

Pintér, E., & Szolcsànyi, J. (1988). Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat. Agents and Actions, 25(3-4), 240-242. https://doi.org/10.1007/BF01965023

@article{35d8cf3bc1e740e4835c67c6fa20f0d9,

title = "Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat",

abstract = "Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.",

author = "E. Pint{\'e}r and J. Szolcs{\`a}nyi",

year = "1988",

month = sep

day = "1",

doi = "10.1007/BF01965023",

language = "English",

volume = "25",

pages = "240--242",

journal = "Inflammation Research",

issn = "1023-3830",

publisher = "Birkhauser Verlag Basel",

number = "3-4",

}

TY - JOUR

T1 - Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat

AU - Pintér, E.

AU - Szolcsànyi, J.

PY - 1988/9/1

Y1 - 1988/9/1

N2 - Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.

AB - Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.

UR - http://www.scopus.com/inward/record.url?scp=0024226902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024226902&partnerID=8YFLogxK

U2 - 10.1007/BF01965023

DO - 10.1007/BF01965023

M3 - Article

C2 - 3218602

AN - SCOPUS:0024226902

VL - 25

SP - 240

EP - 242

JO - Inflammation Research

JF - Inflammation Research

SN - 1023-3830

IS - 3-4

ER -

Access to Document

10.1007/BF01965023