Inflammatory activation after experimental cardiac tamponade

A. Vass, G. Süveges, D. Érces, M. Nógrády, G. Varga, I. Földesi, M. Futakuchi, M. Imai, N. Okada, H. Okada, M. Borós, J. Kaszaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Purpose: Cardiac tamponade is a medical emergency situation associated with a high rate of life-threatening complications, even after immediate interventions. Our aim was to characterize the acute inflammatory consequences of this event in a clinically relevant large animal model. Methods: Cardiac tamponade was induced for 60 min in anesthetized, ventilated and thoracotomized minipigs by intrapericardial fluid administration, the mean arterial pressure (MAP) being maintained in the interval of 40-45 mm Hg (n = 8). A further group (n = 7) served as sham-operated control. The global macrohemodynamics, including the right- and left-heart end-diastolic volumes (RHEDV and LHEDV), the pulmonary vascular resistance index (PVRI) and the superior mesenteric artery (SMA) flow, were monitored for 240 min, and the intestinal microcirculatory changes (pCO2 gap) were evaluated by indirect tonometry. Blood samples were taken for the determination of cardiac troponin T and vasoactive inflammatory mediators, including histamine, nitrite/nitrate, big-endothelin, superoxide and high-mobility group box protein-1 levels in association with intestinal leukocyte and complement activation. Results: The cardiac tamponade induced significant decreases in MAP, cardiac output, LHEDV and SMA flow, while the PVRI and the pCO2 gap increased significantly. After the removal of fluid from the pericardial sac, the MAP and the LHEDV were decreased, while the PVRI and the pCO2 gap remained elevated when compared with those in the sham-operated group. In the posttamponade period, the abrupt release of inflammatory mediators was accompanied by a significant splanchnic leukocyte accumulation and complement activation. Conclusions: The macrocirculatory and splanchnic microcirculatory disturbances were accompanied by a significant proinflammatory reaction; endothelin and the complement system may be significant components of the inflammatory cascade that is activated in this porcine model of pericardial tamponade.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalEuropean Surgical Research
Volume51
Issue number1-2
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Cardiac Tamponade
Vascular Resistance
Arterial Pressure
Superior Mesenteric Artery
Viscera
Complement Activation
Leukocytes
HMGB1 Protein
Miniature Swine
Troponin T
Pericardium
Endothelins
Manometry
Endothelin-1
Nitrites
Superoxides
Cardiac Output
Nitrates
Histamine
Emergencies

Keywords

  • Big-endothelin
  • Cardiac tamponade
  • High-mobility group box protein-1
  • Histamine
  • Intestinal microcirculation
  • Troponin T

ASJC Scopus subject areas

  • Surgery

Cite this

Inflammatory activation after experimental cardiac tamponade. / Vass, A.; Süveges, G.; Érces, D.; Nógrády, M.; Varga, G.; Földesi, I.; Futakuchi, M.; Imai, M.; Okada, N.; Okada, H.; Borós, M.; Kaszaki, J.

In: European Surgical Research, Vol. 51, No. 1-2, 11.2013, p. 1-13.

Research output: Contribution to journalArticle

Vass, A, Süveges, G, Érces, D, Nógrády, M, Varga, G, Földesi, I, Futakuchi, M, Imai, M, Okada, N, Okada, H, Borós, M & Kaszaki, J 2013, 'Inflammatory activation after experimental cardiac tamponade', European Surgical Research, vol. 51, no. 1-2, pp. 1-13. https://doi.org/10.1159/000352089
Vass, A. ; Süveges, G. ; Érces, D. ; Nógrády, M. ; Varga, G. ; Földesi, I. ; Futakuchi, M. ; Imai, M. ; Okada, N. ; Okada, H. ; Borós, M. ; Kaszaki, J. / Inflammatory activation after experimental cardiac tamponade. In: European Surgical Research. 2013 ; Vol. 51, No. 1-2. pp. 1-13.
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AU - Varga, G.

AU - Földesi, I.

AU - Futakuchi, M.

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