Inflammation profile in overweight/obese adolescents in Europe: An analysis in relation to iron status

M. Ferrari, M. Cuenca-García, J. Valtueña, L. A. Moreno, L. Censi, M. González-Gross, O. Androutsos, C. C. Gilbert, I. Huybrechts, J. Dallongeville, M. Sjöström, D. Molnar, S. De Henauw, S. Gómez-Martínez, A. C.F. De Moraes, A. Kafatos, K. Widhalm, C. Leclercq

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Abstract

Background/Objectives:The objectives of this study were to investigate the relationship between inflammatory parameters (CRP, c-reactive protein; AGP, α1-acid glycoprotein), iron status indicators (SF, serum ferritin; sTfR, soluble transferrin receptor) and body mass index (BMI) z-score, fat-free mass (FFM) and fat mass (FM) in European adolescents. Differences in intake for some nutrients (total iron, haem and non-haem iron, vitamin C, calcium, proteins) were assessed according to BMI categories, and the association of nutrient intakes with BMI z-score, FM and FFM was evaluated.Methods:A total of 876 adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence-Cross Sectional Study were included in the study sample.Results:Mean CRP values (standard error; s.e.) were significantly higher in overweight/obese adolescents (1.7±0.3 and 1.4±0.3 mg/l in boys and girls, respectively) than in thin/normal-weight adolescents (1.1±0.2 and 1.0±0.1 mg/l in boys and girls, respectively) (P<0.05). For boys, mean SF values (s.e.) were significantly higher in overweight/obese adolescents (46.9±2.7 μg/l) than in thin/normal-weight adolescents (35.7±1.7 μg/l) (P<0.001), whereas median sTfR values did not differ among BMI categories for both boys and girls. Multilevel regression analyses showed that BMI z-score and FM were significantly related to CRP and AGP (P<0.05). Dietary variables did not differ significantly among BMI categories, except for the intake of vegetable proteins, which, for boys, was higher in thin/normal-weight adolescents than in overweight/obese adolescents (P<0.05).Conclusions:The adiposity of the European adolescents was sufficient to cause chronic inflammation but not sufficient to impair iron status and cause iron deficiency.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalEuropean Journal of Clinical Nutrition
Volume69
Issue number2
DOIs
Publication statusPublished - Feb 5 2015

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Ferrari, M., Cuenca-García, M., Valtueña, J., Moreno, L. A., Censi, L., González-Gross, M., Androutsos, O., Gilbert, C. C., Huybrechts, I., Dallongeville, J., Sjöström, M., Molnar, D., De Henauw, S., Gómez-Martínez, S., De Moraes, A. C. F., Kafatos, A., Widhalm, K., & Leclercq, C. (2015). Inflammation profile in overweight/obese adolescents in Europe: An analysis in relation to iron status. European Journal of Clinical Nutrition, 69(2), 247-255. https://doi.org/10.1038/ejcn.2014.154