Inflammation in metabolically healthy and metabolically abnormal adolescents

The HELENA study

the HELENA study group, the HELENA study group

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Body Mass Index
Inflammation
C-Reactive Protein
Metabolome
Health
Interleukin-6
Complement C3
Cell Adhesion Molecules
Health Status
Triglycerides
Chronic Disease
Tumor Necrosis Factor-alpha
Cross-Sectional Studies
Biomarkers
Cholesterol
Hypertension
Glucose

Keywords

  • adolescents
  • Inflammation
  • Inflammatory biomarkers
  • Metabolic health
  • Metabolic syndrome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Inflammation in metabolically healthy and metabolically abnormal adolescents : The HELENA study. / the HELENA study group; the HELENA study group.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 28, No. 1, 01.01.2018, p. 77-83.

Research output: Contribution to journalArticle

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title = "Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study",
abstract = "Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.",
keywords = "adolescents, Inflammation, Inflammatory biomarkers, Metabolic health, Metabolic syndrome",
author = "{the HELENA study group} and {the HELENA study group} and Gonz{\'a}lez-Gil, {E. M.} and C. Cadenas-Sanchez and J. Santab{\'a}rbara and G. Bueno-Lozano and I. Iglesia and M. Gonz{\'a}lez-Gross and D. Moln{\'a}r and F. Gottrand and {De Henauw}, S. and A. Kafatos and K. Widhalm and Y. Manios and A. Siani and F. Amaro-Gahete and Rup{\'e}rez, {A. I.} and D. Ca{\~n}ada and L. Censi and M. Kersting and J. Dallongeville and A. Marcos and Ortega, {F. B.} and Moreno, {L. A.} and Moreno, {L. A.} and F. Gottrand and {De Henauw}, S. and M. Gonz{\'a}lez-Gross and C. Gilbert and A. Kafatos and C. Libersa and S. Castell{\'o} and M. Kersting and M. Sj{\"o}strom and D. Moln{\'a}r and J. Dallongeville and G. Hall and L. Maes and L. Scalfi and P. Mel{\'e}ndez and J. Fleta and Casaj{\'u}s, {J. A.} and G. Rodr{\'i}guez and C. Tom{\'a}s and Mesana, {M. I.} and G. Vicente-Rodr{\'i}guez and A. Villarroya and Gil, {C. M.} and I. Ara and Alvira, {J. F.} and G. Bueno and A. L{\'a}zaro",
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T1 - Inflammation in metabolically healthy and metabolically abnormal adolescents

T2 - The HELENA study

AU - the HELENA study group

AU - the HELENA study group

AU - González-Gil, E. M.

AU - Cadenas-Sanchez, C.

AU - Santabárbara, J.

AU - Bueno-Lozano, G.

AU - Iglesia, I.

AU - González-Gross, M.

AU - Molnár, D.

AU - Gottrand, F.

AU - De Henauw, S.

AU - Kafatos, A.

AU - Widhalm, K.

AU - Manios, Y.

AU - Siani, A.

AU - Amaro-Gahete, F.

AU - Rupérez, A. I.

AU - Cañada, D.

AU - Censi, L.

AU - Kersting, M.

AU - Dallongeville, J.

AU - Marcos, A.

AU - Ortega, F. B.

AU - Moreno, L. A.

AU - Moreno, L. A.

AU - Gottrand, F.

AU - De Henauw, S.

AU - González-Gross, M.

AU - Gilbert, C.

AU - Kafatos, A.

AU - Libersa, C.

AU - Castelló, S.

AU - Kersting, M.

AU - Sjöstrom, M.

AU - Molnár, D.

AU - Dallongeville, J.

AU - Hall, G.

AU - Maes, L.

AU - Scalfi, L.

AU - Meléndez, P.

AU - Fleta, J.

AU - Casajús, J. A.

AU - Rodríguez, G.

AU - Tomás, C.

AU - Mesana, M. I.

AU - Vicente-Rodríguez, G.

AU - Villarroya, A.

AU - Gil, C. M.

AU - Ara, I.

AU - Alvira, J. F.

AU - Bueno, G.

AU - Lázaro, A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.

AB - Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.

KW - adolescents

KW - Inflammation

KW - Inflammatory biomarkers

KW - Metabolic health

KW - Metabolic syndrome

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U2 - 10.1016/j.numecd.2017.10.004

DO - 10.1016/j.numecd.2017.10.004

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VL - 28

SP - 77

EP - 83

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

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