Inflammasomes in liver diseases

G. Szabó, Timea Csak

Research output: Contribution to journalReview article

210 Citations (Scopus)

Abstract

Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1α, IL-1β, and TNFα. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1β and IL-18. The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review.

Original languageEnglish
Pages (from-to)642-654
Number of pages13
JournalJournal of Hepatology
Volume57
Issue number3
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Inflammasomes
Interleukin-1
Liver Diseases
Inflammation
Fibrosis
Multiprotein Complexes
Caspase 1
Interleukin-18
Fatty Liver
Liver Cirrhosis
Chronic Disease
Cytokines
Liver

Keywords

  • Caspase-1
  • Drug induced liver injury
  • Endotoxin
  • Fibrosis
  • Inflammasomes
  • Interleukin-1ß
  • Ischaemiareperfusion
  • Steatohepatitis
  • Viral hepatitis

ASJC Scopus subject areas

  • Hepatology

Cite this

Inflammasomes in liver diseases. / Szabó, G.; Csak, Timea.

In: Journal of Hepatology, Vol. 57, No. 3, 09.2012, p. 642-654.

Research output: Contribution to journalReview article

Szabó, G. ; Csak, Timea. / Inflammasomes in liver diseases. In: Journal of Hepatology. 2012 ; Vol. 57, No. 3. pp. 642-654.
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