Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis

G. Szabó, Arvin Iracheta-Vellve

Research output: Contribution to journalShort survey

11 Citations (Scopus)

Abstract

Upregulation of the inflammatory cascade is a major element both in the progression of steatohepatitis to severe alcoholic hepatitis as well as in the progression of NASH to advanced NASH with fibrosis. The mechanisms underpinning these changes are only partially understood. Activation of the inflammatory cascade requires multiple stimuli and in this report, we discuss the role of inflammasomes that activate IL-1β as well as the sterile and pathogen-derived danger signals that results in inflammasome activation and inflammation in alcoholic and non-alcoholic steatohepatitis. The dynamics of inflammasome activation, the cell types involved and the trigger signals appear to be somewhat different between ASH and NASH. Further studies are needed to dissect the pathology-related differences between these two major forms of steatohepatitis. Clinical and therapeutic implications of inflammasome activation in steatohepatitis are also discussed.

Original languageEnglish
Pages (from-to)S18-S23
JournalClinics and Research in Hepatology and Gastroenterology
Volume39
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Inflammasomes
Fatty Liver
Liver
Alcoholic Hepatitis
Interleukin-1
Fibrosis
Up-Regulation
Pathology
Inflammation

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Inflammasome activation in the liver : Focus on alcoholic and non-alcoholic steatohepatitis. / Szabó, G.; Iracheta-Vellve, Arvin.

In: Clinics and Research in Hepatology and Gastroenterology, Vol. 39, 01.09.2015, p. S18-S23.

Research output: Contribution to journalShort survey

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