Infectious keratitis caused by Aspergillus tubingensis

László Kredics, János Varga, Sándor Kocsubé, Revathi Rajaraman, Anita Raghavan, Ilona Dóczi, Madhavan Bhaskar, Tibor Mihály Németh, Zsuzsanna Antal, Narendran Venkatapathy, Csaba Vágvölgyi, Robert A. Samson, Manoharan Chockaiya, Manikandan Palanisamy

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PURPOSE: To report 2 cases of keratomycosis caused by Aspergillus tubingensis. METHODS: The therapeutic courses were recorded for 2 male patients, 52 and 78 years old, with fungal keratitis caused by black Aspergillus strains. Morphological examination of the isolates was carried out on malt extract agar plates. A segment of the β-tubulin gene was used for molecular identification. Antifungal susceptibilities were determined by the E test method for molds and the broth microdilution technique National Committee for Clinical Laboratory Standards M38-A. RESULTS: A 52-year-old man presented with complaints of pain and redness in the right eye. The patient was successfully treated with natamycin and econazole eyedrops, itraconazole eye ointment, and oral ketoconazole. A 78-year-old man presented with total corneal necrosis in the right eye. A therapeutic keratoplasty was performed, and topical natamycin and econazole were applied. At the postoperative visit after 3 weeks, almost the full corneal graft was clear with formed anterior chamber. Black Aspergillus strains were isolated from the corneal scrapings of both cases and initially identified as Aspergillus niger based on culture characteristics. Sequence analysis of a segment of the β-tubulin gene revealed that the isolates are representatives of A. tubingensis. CONCLUSIONS: Aspergillus tubingensis is closely related with A. niger, the differentiation of these 2 species is difficult by classical morphological criteria. To our knowledge, the presented cases of fungal keratitis are the first reports on ocular infection caused by A. tubingensis.

Original languageEnglish
Pages (from-to)951-954
Number of pages4
Issue number8
Publication statusPublished - Sep 1 2009



  • Aspergillus tubingensis
  • Corneal ulcer
  • Fungal keratitis
  • Keratomycosis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kredics, L., Varga, J., Kocsubé, S., Rajaraman, R., Raghavan, A., Dóczi, I., Bhaskar, M., Németh, T. M., Antal, Z., Venkatapathy, N., Vágvölgyi, C., Samson, R. A., Chockaiya, M., & Palanisamy, M. (2009). Infectious keratitis caused by Aspergillus tubingensis. Cornea, 28(8), 951-954.