Infectious diseases of the respiratory system during pregnancy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Infectious diseases of respiratory system frequently complicate pregnancy. Thisreview evaluates the possible association between maternal infectious diseases of therespiratory system during pregnancy and preterm birth or structural birth defects, i.e.,congenital abnormalities (CAs), in addition to their pregnancy complications based onthe data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities.At the evaluation of a common cold, it is necessary to differentiate the usualcommon cold (with short duration and without fever) and the common cold withsecondary complications (i.e., with longer duration and frequently high fever). Pregnantwomen with a common cold mainly with secondary complications did not have a higherincidence of pregnancy complications. The gestational age at delivery was 0.1 weekshorter with a somewhat higher rate of preterm birth, but these differences had no realclinical importance. However, an association of common cold (mainly with secondarycomplications) in the second and/or third gestational month of pregnancy with a higherrate of newborns with congenital cataract, cleft lip ± palate and possibly some otherspecific congenital abnormalities was found, and this association was preventable withantifever drug treatments.Acute infectious diseases of the respiratory system cover a wide spectrum ofdiseases, from sinusitis to pneumonia. These diseases during pregnancy have no obviouseffect of pregnancy complications. Infectious respiratory diseases in the severe lowercatetory were associated with a higher risk for preterm birth, but their mild uppercategory seems to reduce indirectly the rate of preterm birth. Acute infectious diseases ofthe respiratory system during the second and third gestational months of pregnancy werenot associated with a higher risk for the total group or any specific group/entity ofcongenital abnormalities. However, frequently high-fever-related tonsillitis in pregnantwomen was associated with a higher risk for congenital cataract, neural-tube defects,cleft lip ± palate and unclassified multiple congenital abnormalities. We may supposethat the association between these fever-sensitive defect groups and tonsillitis may becaused by high fever, because the parallel antifever treatment was able to prevent thisrisk.Finally, influenza during pregnancy was evaluated. The short duration of influenzain pregnant women did not increase the risk for pregnancy complications. Our studyshowed that the appropriately treated pregnant women affected with influenza in the firstand second trimester of pregnancy have no higher risk for preterm birth. However, thehigh- fever-related influenza in the second and/or third gestational month of pregnancymay associate with a higher risk of some hyperthermia-sensitive CAs such as neural-tubedefects, congenital cataract, cleft lip ± palate, cleft palate only, cardiovascular CAs, andunclassified multiple CAs. The main finding of our study is that this higher risk for thesemajor CAs can be prevented by the parallel use of antifever drugs.

Original languageEnglish
Title of host publicationInfectious Pregnancy Complications
PublisherNova Science Publishers, Inc.
Pages383-406
Number of pages24
ISBN (Print)9781607410386
Publication statusPublished - Mar 2009

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Respiratory System
Communicable Diseases
Pregnancy
Fever
Premature Birth
Common Cold
Pregnancy Complications
Cleft Palate
Cleft Lip
Cataract
Human Influenza
Multiple Abnormalities
Tonsillitis
Acute Disease
Pregnant Women
Cardiovascular Abnormalities
Neural Tube Defects
Sinusitis
Second Pregnancy Trimester
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Czeizel, E., Ács, N., & Bánhidy, F. (2009). Infectious diseases of the respiratory system during pregnancy. In Infectious Pregnancy Complications (pp. 383-406). Nova Science Publishers, Inc..

Infectious diseases of the respiratory system during pregnancy. / Czeizel, E.; Ács, N.; Bánhidy, F.

Infectious Pregnancy Complications. Nova Science Publishers, Inc., 2009. p. 383-406.

Research output: Chapter in Book/Report/Conference proceedingChapter

Czeizel, E, Ács, N & Bánhidy, F 2009, Infectious diseases of the respiratory system during pregnancy. in Infectious Pregnancy Complications. Nova Science Publishers, Inc., pp. 383-406.
Czeizel E, Ács N, Bánhidy F. Infectious diseases of the respiratory system during pregnancy. In Infectious Pregnancy Complications. Nova Science Publishers, Inc. 2009. p. 383-406
Czeizel, E. ; Ács, N. ; Bánhidy, F. / Infectious diseases of the respiratory system during pregnancy. Infectious Pregnancy Complications. Nova Science Publishers, Inc., 2009. pp. 383-406
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