Infectious diseases of respiratory system during pregnancy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Infectious diseases of respiratory system frequently complicate pregnancy. This review is to evaluate the possible association between maternal infectious diseases of respiratory system during pregnancy and preterm birth or structural birth defects, i.e. congenital abnormalities (CAs), in addition their pregnancy complications based on the data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities. At the evaluation of common cold, it is necessary to differentiate the usual common cold (with short duration and without fever) and common cold with secondary complications (i.e. with longer duration and frequently high fever). Pregnant women with common cold mainly with secondary complications had not a higher incidence of pregnancy complications. The gestational age at delivery was 0.1 week shorter with a somewhat higher rate of preterm birth, but these differences had no real clinical importance. However, an association of common cold (mainly with secondary complications) in the second and/or third gestational month of pregnancy with a higher rate of newborns with congenital cataract, cleft lip + palate and possible some other specific congenital abnormalities was found and these association was preventable with antifever drug treatments. Acute infectious diseases of respiratory system cover a wide spectrum of diseases from sinusitis to pneumonia. These diseases during pregnancy have no obvious effect for pregnancy complications. Severe lower category of these infectious respiratory diseases associated with a higher risk for preterm birth, but their mild upper category seems to reduce indirectly the rate of preterm birth. Acute infectious diseases of respiratory system during the second and third gestational months of pregnancy did not associate with ahigher risk for the total group or any specific group/entity of congenital abnormalities. However, the frequently high fever related tonsillitis in pregnant women associated with a higher risk for congenital cataract, neural-tube defects, cleft lip + palate and unclassified multiple congenital abnormalities. We may suppose that the association between these fever sensitive defect groups and tonsillitis may be caused by high fever, because the parallel antifever treatment was able to prevent this risk. Finally the influenza during pregnancy was evaluated. The short duration of influenza in pregnant women did not increase the risk for pregnancy complications. Our study showed that the appropriately treated pregnant women affected with influenza in the first and second trimester of pregnancy have no higher risk for preterm birth. However, the high fever related influenza in the second and/or third gestational month of pregnancy may associate with a higher risk of some - hyperthermia sensitive - CAs such as neural-tube defects, congenital cataract, cleft lip + palate, cleft palate only, cardiovascular CAs, and unclassified multiple CAs. The main finding of our study is that this higher risk for these major CA can be prevented by the parallel use of antifever drugs.

Original languageEnglish
Title of host publicationHandbook of Down Syndrome Research
PublisherNova Science Publishers, Inc.
Pages183-206
Number of pages24
ISBN (Print)9781607416906
Publication statusPublished - 2009

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Respiratory System
Communicable Diseases
Common Cold
Pregnancy
Fever
Premature Birth
Pregnancy Complications
Cleft Palate
Human Influenza
Pregnant Women
Cleft Lip
Cataract
Multiple Abnormalities
Tonsillitis
Neural Tube Defects
Acute Disease
Cardiovascular Abnormalities
Sinusitis
Second Pregnancy Trimester
First Pregnancy Trimester

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Czeizel, E., Ács, N., & Bánhidy, F. (2009). Infectious diseases of respiratory system during pregnancy. In Handbook of Down Syndrome Research (pp. 183-206). Nova Science Publishers, Inc..

Infectious diseases of respiratory system during pregnancy. / Czeizel, E.; Ács, N.; Bánhidy, F.

Handbook of Down Syndrome Research. Nova Science Publishers, Inc., 2009. p. 183-206.

Research output: Chapter in Book/Report/Conference proceedingChapter

Czeizel, E, Ács, N & Bánhidy, F 2009, Infectious diseases of respiratory system during pregnancy. in Handbook of Down Syndrome Research. Nova Science Publishers, Inc., pp. 183-206.
Czeizel E, Ács N, Bánhidy F. Infectious diseases of respiratory system during pregnancy. In Handbook of Down Syndrome Research. Nova Science Publishers, Inc. 2009. p. 183-206
Czeizel, E. ; Ács, N. ; Bánhidy, F. / Infectious diseases of respiratory system during pregnancy. Handbook of Down Syndrome Research. Nova Science Publishers, Inc., 2009. pp. 183-206
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