Induction of taurine responsiveness in Xenopus oocytes by messenger RNA from mouse brain

Atsushi Asanuma, Tetsuro Horikoshi, Keiji Yanagisawa, Kaijiro Anzai, Sataro Goto, Tohru Yoshioka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A taurine response was induced in the surface membrane of the oocytes of Xenopus laevis by injection of the mRNA from the neonatal mouse brain, and the response was studied electrophysiologically. The permeability of mRNA-injected oocytes to chloride ions was increased by the application of taurine in a dose-dependent manner. The same oocyte also responded to GABA, but bicuculline suppressed only the GABA response. These results suggest a possibility that taurine could be a neurotransmitter of certain neurons as yet unknown in the central nervous system.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalNeuroscience Letters
Volume69
Issue number3
DOIs
Publication statusPublished - Sep 12 1986

Keywords

  • Bicuculline
  • Mouse brain
  • Oocyte
  • Receptor
  • Taurine
  • mRNA
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Induction of taurine responsiveness in Xenopus oocytes by messenger RNA from mouse brain'. Together they form a unique fingerprint.

  • Cite this