Induction of Rat Hepatic Drug Metabolizing Enzymes by Substituted Urea Herbicides

Bernadette Schoket, István Vincze

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Effects of eight structurally closely related substituted urea herbicides were investigated on the induction of cytochrome P‐450 dependent monooxygenase enzyme complex, as well as on two conjugating enzymes after short‐term treatment of rats. Liver microsomal cytochrome P‐450 content was induced approximately by 50%. Cytochrome P‐450 dependent monooxygenase activities showed a great variety depending on the substrate and on the herbicide. Two‐18‐fold induction was detected with 7‐ethoxycoumarin, while up to 8‐fold induction was measured with benzo(a)pyrene. Aldrin epoxidase activities were increased up to 3‐fold, and aminopyrine N‐demethylase activities were only slightly different from the control level. UDP‐glucuronyltransferase and glutathione S‐transferase activities were enhanced up to 2‐fold. The results indicate that chemical structure of the related substituted urea compounds, the number of halogen substituents on their phenyl group exert a strong influence on the induction of monooxygenases. 1985 Nordic Pharmacological Society

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalActa Pharmacologica et Toxicologica
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 1985

Keywords

  • Herbicides
  • UDP‐glucuronyltransferase
  • cytochrome P‐450
  • glutathione S‐transferase
  • liver
  • monooxygenases
  • rat
  • substituted urea

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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