INDUKTION PARTIELLER IMMUNTOLERANZ IM NAH VERWANDTEN SPEZIESSYSTEM DURCH EINMALIGE INJEKTION EINES MIT PAPAIN GEWONNENEN, SPENDERSPEZIES-SPEZIFISCHEN LYMPHOZYTENMEMBRAN-ANTIGENS

Translated title of the contribution: Induction of partial immunotolerance in a closely related species system by a single injection of a donor species specific lymphocyte membrane antigen using papain

C. H. Prange, M. Kessler, D. Bach, F. Huth

Research output: Contribution to journalArticle

Abstract

This paper reports experimental xenografting of kidneys in closely related species (fox-dog) modifying primary graft rejection by single i.v. injection of donor-species-specific lymphocyte antigen in soluble form. Papain treatment was used to separate histocompatibility antigens from lymphocytes of donors. This antigen, in vitro, is capable of reducing cytotoxicity of xeno-antisera by adsorption of their lymphocytotoxic antibodies. A single intraoperative i.v. injection of this antigen to the transplant recipients results in the subsequent failure of humoral antibody production, thus this antigen-mediated effect is thought to be a state of B-cell tolerance. Survival times are more than doubled in comparison to untreated controls and last for an average of 14.6 ± 1.74 days (n = 5). Histological studies demonstrate rather well conserved renal parenchyma with sporadic infiltration of round cells.

Original languageGerman
Pages (from-to)28-37
Number of pages10
JournalZeitschrift fur Experimentelle Chirurgie
Volume13
Issue number1
Publication statusPublished - 1980

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Papain
Tissue Donors
Lymphocytes
Antigens
Injections
Membranes
Kidney
Heterologous Transplantation
Histocompatibility Antigens
Antilymphocyte Serum
Graft Rejection
Adsorption
Antibody Formation
Immune Sera
B-Lymphocytes
Dogs
Survival
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "INDUKTION PARTIELLER IMMUNTOLERANZ IM NAH VERWANDTEN SPEZIESSYSTEM DURCH EINMALIGE INJEKTION EINES MIT PAPAIN GEWONNENEN, SPENDERSPEZIES-SPEZIFISCHEN LYMPHOZYTENMEMBRAN-ANTIGENS",
abstract = "This paper reports experimental xenografting of kidneys in closely related species (fox-dog) modifying primary graft rejection by single i.v. injection of donor-species-specific lymphocyte antigen in soluble form. Papain treatment was used to separate histocompatibility antigens from lymphocytes of donors. This antigen, in vitro, is capable of reducing cytotoxicity of xeno-antisera by adsorption of their lymphocytotoxic antibodies. A single intraoperative i.v. injection of this antigen to the transplant recipients results in the subsequent failure of humoral antibody production, thus this antigen-mediated effect is thought to be a state of B-cell tolerance. Survival times are more than doubled in comparison to untreated controls and last for an average of 14.6 ± 1.74 days (n = 5). Histological studies demonstrate rather well conserved renal parenchyma with sporadic infiltration of round cells.",
author = "Prange, {C. H.} and M. Kessler and D. Bach and F. Huth",
year = "1980",
language = "German",
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publisher = "Berlin Verlag Volk Und Gesundheit",
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AU - Prange, C. H.

AU - Kessler, M.

AU - Bach, D.

AU - Huth, F.

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AB - This paper reports experimental xenografting of kidneys in closely related species (fox-dog) modifying primary graft rejection by single i.v. injection of donor-species-specific lymphocyte antigen in soluble form. Papain treatment was used to separate histocompatibility antigens from lymphocytes of donors. This antigen, in vitro, is capable of reducing cytotoxicity of xeno-antisera by adsorption of their lymphocytotoxic antibodies. A single intraoperative i.v. injection of this antigen to the transplant recipients results in the subsequent failure of humoral antibody production, thus this antigen-mediated effect is thought to be a state of B-cell tolerance. Survival times are more than doubled in comparison to untreated controls and last for an average of 14.6 ± 1.74 days (n = 5). Histological studies demonstrate rather well conserved renal parenchyma with sporadic infiltration of round cells.

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