Induction of ligand carrying 'natural liposomes' in cancer cells

J. Timar, N. Bradley, D. Robertson, A. J.S. Davies

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Abstract

N-ethyl-maleimide (NEM) induced plasma membrane vesiculation of human cancer cell line EJ was studied in vitro using immunoelectromicroscopic methods. We have demonstrated the presence of plasma membrane glycoconjugates and antigens on these vesicles. The effect of NEM or Ricin-antiRicin antibody complex internalisation was also followed. It was revealed that NEM is able to block the internalisation and stimulate the recycling arm of the complex-traffic. Multivesicular endosome-derived plasma membrane vesicles play import role in this recycling. According to the presented evidences it is possible to produce ligands carrying 'natural liposomes'.

Original languageEnglish
Pages (from-to)299-310
Number of pages12
JournalActa morphologica Hungarica
Volume34
Issue number4
Publication statusPublished - Dec 1 1986

ASJC Scopus subject areas

  • Anatomy

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    Timar, J., Bradley, N., Robertson, D., & Davies, A. J. S. (1986). Induction of ligand carrying 'natural liposomes' in cancer cells. Acta morphologica Hungarica, 34(4), 299-310.