Induction of human rheumatoid factor and other autoantibodies by bacterial lipopolysaccharide.

K. Németh, A. Falus, E. Elekes, U. Böhm, K. Merétey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In vitro autoantibody production induced by lipopolysaccharide (LPS) was studied using peripheral blood mononuclear (PBM) cell suspensions from patients with rheumatoid arthritis (RA) and healthy subjects. PBMs from both groups could be induced by LPS to secrete IgM and IgA rheumatoid factors (RF), antinuclear and anti-beta-2-microglobulin autoantibodies. Spontaneous production of IgM-RF was considerably higher in RA than in controls. The rate of IgM-RF and IgA-RF secretion detected by ELISA increased with the dose of LPS in cultures of both groups. In RA, differences were found between the kinetics of IgM- and IgA-RFs secretion. LPS augmented the relative avidity of IgM-RF produced by PBMs from RA patients and this value was significantly higher than that of healthy persons. In some cases RFs cross-reacting with nuclear antigens and beta-2-microglobulin were detected.

Original languageEnglish
Pages (from-to)249-258
Number of pages10
JournalActa Microbiologica Hungarica
Volume32
Issue number3
Publication statusPublished - 1985

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Rheumatoid Factor
Autoantibodies
Immunoglobulin M
Lipopolysaccharides
Rheumatoid Arthritis
Immunoglobulin A
beta 2-Microglobulin
Nuclear Antigens
Blood Cells
Suspensions
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
phytobacteriomycin

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Induction of human rheumatoid factor and other autoantibodies by bacterial lipopolysaccharide. / Németh, K.; Falus, A.; Elekes, E.; Böhm, U.; Merétey, K.

In: Acta Microbiologica Hungarica, Vol. 32, No. 3, 1985, p. 249-258.

Research output: Contribution to journalArticle

Németh, K. ; Falus, A. ; Elekes, E. ; Böhm, U. ; Merétey, K. / Induction of human rheumatoid factor and other autoantibodies by bacterial lipopolysaccharide. In: Acta Microbiologica Hungarica. 1985 ; Vol. 32, No. 3. pp. 249-258.
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