Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells

E. Oláh, Y. Natsumeda, T. Ikegami, Z. Kote, M. Horányi, J. Szelényi, E. Paulik, T. Kremmer, S. Hollán, J. Sugar, G. Weber

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Abstract

Tiazofurin (2-β-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP dehydrogenase (IMP:NAD+ oxidoreductase; EC 1.1.1.205) and depletes guanylate levels, can activate the erythroid differentiation program of K-562 human leukemia cells. Tiazofurin-mediated cell differentiation is a multistep process. The inducer initiates early (

Original languageEnglish
Pages (from-to)6533-6537
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number17
Publication statusPublished - 1988

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tiazofurin
IMP Dehydrogenase
Leukemia
Gene Expression
Thiazoles
Nucleosides
Cell Differentiation
Carbon

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells. / Oláh, E.; Natsumeda, Y.; Ikegami, T.; Kote, Z.; Horányi, M.; Szelényi, J.; Paulik, E.; Kremmer, T.; Hollán, S.; Sugar, J.; Weber, G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, No. 17, 1988, p. 6533-6537.

Research output: Contribution to journalArticle

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T1 - Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells

AU - Oláh, E.

AU - Natsumeda, Y.

AU - Ikegami, T.

AU - Kote, Z.

AU - Horányi, M.

AU - Szelényi, J.

AU - Paulik, E.

AU - Kremmer, T.

AU - Hollán, S.

AU - Sugar, J.

AU - Weber, G.

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