Induction of antiviral response by electric pulses

Krisztina Kovács, Ferenc Somogyvári, Bratko Filipic, Imre Mécs, Sándor Tóth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Antiviral activity was detected in porcine leukocytes obtained from animals killed in a slaughterhouse. The activity appeared in the supernatant immediately after the addition of Sendai virus, an intended interferon (IFN) inducer. Electroinduction appears to be responsible for the production of antiviral molecules in both porcine and human leukocytes. The macromolecule conferring the antiviral activity is sensitive to heat and pH 2.0 treatment. The preformed or electroinduced antiviral activity originating from porcine leukocytes was not neutralized by either anti-PoIFN-α or anti-PoIFN-γ. The substance involved differs from all known antiviral proteins in that it is not secreted spontaneously into the extracellular space. Its release requires intact and virulent Sendai virus as a trigger signal. Differences in antigenic properties and characteristics indicate that this is a new antiviral substance.

Original languageEnglish
Pages (from-to)279-287
Number of pages9
JournalElectro- and magnetobiology
Volume19
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

ASJC Scopus subject areas

  • Biophysics
  • Agricultural and Biological Sciences (miscellaneous)

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