Induction of anti-Escherichia coli activity in mice by phenothiazines, benzo[a]phenothiazines and benz[c]acridines

N. Motohashi, H. Sakagami, N. Komatsu, M. Fujimaki, C. Wada, J. Molnar

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The abilities of 14 phenothiazines, 8 benzo[a]phenothiazines and 12 benz[c]acridines to induce anti-Escherichia coli activity in mice were compared. Pretreatment with several benzo[a]phenothiazines or benz[c]acridines protected mice from lethal infection of Escherichia coli in a dose-dependent manner, whereas most of the phenothiazines induced much weaker anti-Escherichia coli activity. However, direct contact of Escherichia coli with these compounds or their administation just after bacterial inoculation were ineffective. These data suggest the immunopotentiation activity of benzo[a]phenothiazines and benz[c]acridines.

Original languageEnglish
Pages (from-to)585-588
Number of pages4
JournalIn Vivo
Volume6
Issue number6
Publication statusPublished - Dec 1 1992

Keywords

  • antimicrobial activity
  • benzo[a]phenothiazines
  • immunopotentiation
  • phenothiazines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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  • Cite this

    Motohashi, N., Sakagami, H., Komatsu, N., Fujimaki, M., Wada, C., & Molnar, J. (1992). Induction of anti-Escherichia coli activity in mice by phenothiazines, benzo[a]phenothiazines and benz[c]acridines. In Vivo, 6(6), 585-588.