Induction of alpha interferon by human immunodeficiency virus type 1 in human monocyte-macrophage cultures

J. Szebeni, C. Dieffenbach, S. M. Wahl, C. N. Venkateshan, A. Yeh, M. Popovic, S. Gartner, L. M. Wahl, M. Peterfy, R. M. Friedman, J. N. Weinstein

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Abstract

The induction of interferon (IFN) by human immunodeficiency virus type 1 (HIV-1) in primary, nonstimulated monocyte-macrophage cultures was studied. HIV-1 infection, as confirmed by p24 antigen levels in the cell supernatant, led to the production of alpha interferon (IFN-α) over 7 to 21 days following infection. In two of seven experiments, the IFN detected was acid labile. Coupled reverse transcription-polymerase chain reaction analysis confirmed the induction of IFN-α mRNA in cells of HIV-1-infected cultures.

Original languageEnglish
Pages (from-to)6362-6364
Number of pages3
JournalJournal of Virology
Volume65
Issue number11
DOIs
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Szebeni, J., Dieffenbach, C., Wahl, S. M., Venkateshan, C. N., Yeh, A., Popovic, M., Gartner, S., Wahl, L. M., Peterfy, M., Friedman, R. M., & Weinstein, J. N. (1991). Induction of alpha interferon by human immunodeficiency virus type 1 in human monocyte-macrophage cultures. Journal of Virology, 65(11), 6362-6364. https://doi.org/10.1128/jvi.65.11.6362-6364.1991