Induction and activation of tissue transglutaminase during programmed cell death

Laszlo Fesus, Vilmos Thomazy, Andras Falus

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During the involution of lead nitrate-induced hyperplasia in rat liver a significant increase of transglutaminase activity, enzyme concentration, transglutaminase messenger RNA and protein-bound ε-(γ-glutamyl)lysine (product of transglutaminase action) coincided with programmed death (apoptosis) of hepatocytes. Immunohistochemical examination showed the appearance of transglutaminase in apoptotic hepatocytes. An increased transglutaminase level was also detected during glucocorticoid-induced apoptosis of rat thymocytes.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalFEBS letters
Issue number1
Publication statusPublished - Nov 16 1987



  • Apoptosis
  • Hepatocyte
  • Thymocyte
  • Transglutaminase
  • mRNA
  • ε-(γ-Glutamyl)lysine

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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