Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists

István Borza, Sándor Kolok, Györgyi Ignácz-Szendrei, István Greiner, G. Tárkányi, Kornél Galgóczy, Csilla Horváth, Sándor Farkas, György Domány

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activity of the compounds was studied. Compound 5a was po active in the formalin test in mouse.

Original languageEnglish
Pages (from-to)5439-5441
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number24
DOIs
Publication statusPublished - Dec 15 2005

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N-Methyl-D-Aspartate Receptors
Pain Measurement
Bioactivity
Skeleton
Formaldehyde
Substitution reactions
Derivatives
indole
NR2B NMDA receptor

Keywords

  • Indole-2-carboxamidine
  • NB2B
  • NMDA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Borza, I., Kolok, S., Ignácz-Szendrei, G., Greiner, I., Tárkányi, G., Galgóczy, K., ... Domány, G. (2005). Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 15(24), 5439-5441. https://doi.org/10.1016/j.bmcl.2005.08.110

Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists. / Borza, István; Kolok, Sándor; Ignácz-Szendrei, Györgyi; Greiner, István; Tárkányi, G.; Galgóczy, Kornél; Horváth, Csilla; Farkas, Sándor; Domány, György.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 24, 15.12.2005, p. 5439-5441.

Research output: Contribution to journalArticle

Borza, I, Kolok, S, Ignácz-Szendrei, G, Greiner, I, Tárkányi, G, Galgóczy, K, Horváth, C, Farkas, S & Domány, G 2005, 'Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 24, pp. 5439-5441. https://doi.org/10.1016/j.bmcl.2005.08.110
Borza, István ; Kolok, Sándor ; Ignácz-Szendrei, Györgyi ; Greiner, István ; Tárkányi, G. ; Galgóczy, Kornél ; Horváth, Csilla ; Farkas, Sándor ; Domány, György. / Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 24. pp. 5439-5441.
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