Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

István Borza, Sándor Kolok, Anikó Gere, Éva Ágai-Csongor, Béla Ágai, Gábor Tárkányi, Csilla Horváth, Gizella Barta-Szalai, Éva Bozó, Csilla Kiss, Attila Bielik, József Nagy, Sándor Farkas, György Domány

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32 Citations (Scopus)

Abstract

A novel series of indole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the number and position of OH groups on the indole skeleton as well as the substitution of the piperidine ring on the biological activity of the compounds was studied.

Original languageEnglish
Pages (from-to)3859-3861
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number21
DOIs
Publication statusPublished - Nov 3 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Borza, I., Kolok, S., Gere, A., Ágai-Csongor, É., Ágai, B., Tárkányi, G., Horváth, C., Barta-Szalai, G., Bozó, É., Kiss, C., Bielik, A., Nagy, J., Farkas, S., & Domány, G. (2003). Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 13(21), 3859-3861. https://doi.org/10.1016/S0960-894X(03)00708-X