Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban

Translated title of the contribution: Individual evaluation of loreta abnormalities in idiopathic generalized epilepsy

B. Clemens, Szilvia Puskás, Mónika Besenyei, I. Kondákor, Katalin Hollódy, A. Fogarasi, Katalin Bense, M. Emri, Gábor Opposits, Noémi Zsuzsanna Kovács, I. Fekete

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Abstract

Background: Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients. Methods: IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG, variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal. Results: 1. In drug-free condition, 41-50% of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality. Discussion: 1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORE-TA might help to investigate drug effects at the whole-brain level.

Original languageHungarian
Pages (from-to)107-121
Number of pages15
JournalIdeggyógyászati szemle
Volume69
Issue number3-4
DOIs
Publication statusPublished - Mar 30 2016

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Medicine(all)

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