Indirect ultrastructural evidence for lithium uptake by cultured rat cerebral cells through the sodium channel

Z. Janka, D. G. Jones

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cerebral cortices, prepared from 18-day-old rat embryos, were grown in explant cultures for 18 days. They were then incubated for 25 min in media of 3 types of cationic composition with and without tetrodotoxin and/or veratridine. Qualitative and quantitative ultrastructural observations revealed a considerable swelling of neuronal elements following veratridine exposure in both Na+ and Li+ media; this swelling was prevented by tetrodotoxin. By contrast, veratridine failed to induce swelling of neuronal profiles in a choline+ medium. The results indirectly indicate that Li+ ions enter cultured rat cerebral cells through the Na+ channels.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalBrain Research
Volume237
Issue number1
DOIs
Publication statusPublished - Apr 8 1982

Fingerprint

Veratridine
Sodium Channels
Lithium
Tetrodotoxin
Choline
Cerebral Cortex
Embryonic Structures
Ions

Keywords

  • electron microscopy
  • lithium
  • membrane transport
  • rat cerebral cells
  • sodium channel
  • tissue culture

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Indirect ultrastructural evidence for lithium uptake by cultured rat cerebral cells through the sodium channel. / Janka, Z.; Jones, D. G.

In: Brain Research, Vol. 237, No. 1, 08.04.1982, p. 261-266.

Research output: Contribution to journalArticle

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