Indirect methods for determination of the protective effects of coating films on the surface of crystals

J. Bajdik, K. Pintye-Hódi, C. Novák, A. Kelemen, G. Regdon, I. Erös

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The extents of the protective effects of coating films on the surface of crystals were determined. Three different samples were made with different quantities of coating fluid (Sepifilm LP 010 in 10% aqueous solution). Since the atomizing rate was constant, the coating time increased in parallel with the volume of coating fluid applied. The direct measurement of film thickness and smoothness is very difficult, and therefore indirect methods were used. Dimenhydrinate was chosen as model drag; this is a heat-sensitive antihistamine with a low melting point. This temperature can be reached during the tableting process. The behaviour of samples on exposure to heat was examined by differential scanning calorimetry. The water uptakes of the samples were determined with an Enslin apparatus. Plasticity was studied with an instrumented tablet machine. These indirect methods (thermal conductivity, water uptake and plasticity measurements) revealed connections between the results of the various experiments. An overlong coating time decreased the protective effect of the coating film.

Original languageEnglish
Pages (from-to)613-627
Number of pages15
JournalJournal of Thermal Analysis and Calorimetry
Volume68
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

coatings
Coatings
Crystals
crystals
dimenhydrinate
plastic properties
Plasticity
Dimenhydrinate
heat
tablets
Fluids
Water
fluids
Histamine Antagonists
atomizing
water
Tablets
drag
melting points
Drag

Keywords

  • Dimenhydrinate
  • DSC
  • Film coating
  • HPMC
  • Plasticity
  • Thermal conductivity
  • Water uptake

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Indirect methods for determination of the protective effects of coating films on the surface of crystals. / Bajdik, J.; Pintye-Hódi, K.; Novák, C.; Kelemen, A.; Regdon, G.; Erös, I.

In: Journal of Thermal Analysis and Calorimetry, Vol. 68, No. 2, 2002, p. 613-627.

Research output: Contribution to journalArticle

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