Indications and outcome of implantable cardioverter-defibrillators for primary and secondary prophylaxis in patients with noncompaction cardiomyopathy

Kadir Caliskan, Tamas Szili-Torok, Dominic A M J Theuns, A. Kardos, Marcel L. Geleijnse, Aggie H M M Balk, Ron T. Van Domburg, Luc Jordaens, Maarten L. Simoons

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Prophylactic ICDs for Noncompaction Cardiomyopathy. Background: Noncompaction cardiomyopathy (NCCM) is a rare, primary cardiomyopathy, with initial presentation of heart failure, emboli, or arrhythmias, including sudden cardiac death. Implantable cardioverter-defibrillators (ICDs) are frequently used for primary and secondary prevention in different cardiomyopathy patients, but data about ICD in NCCM are scarce. The aim of this study was, therefore, to investigate ICD indications and outcomes in NCCM patients. Methods and Results: We collected prospective data from our NCCM cohort (n = 77 pts, mean age: 40 ± 14 years). ICD was implanted in 44 (57%) patients with NCCM according to the current ICD guidelines for nonischemic cardiomyopathies: in 12 for secondary prevention (7 × ventricular fibrillation, 5 × sustained ventricular tachycardia [VT]) and in 32 patients for primary prevention (heart failure/severe LV dysfunction). During a mean follow-up of 33 ± 24 months, 8 patients presented with appropriate ICD shocks due to sustained VT after median 6.1 [1-16] months. This included 4 of 32 (13%) patients in the primary prevention group and 4 of 12 (33%) in the secondary prevention group (P = 0.04). 9 patients presented with inappropriate ICD therapy: 6 (19%) in the primary and 3 (25%) in the secondary prevention group, at a median follow-up of 4 (2-23) months. Conclusions: In our cohort of NCCM patients, an ICD was frequently implanted for primary or secondary prevention of sudden cardiac death. At follow-up, frequent appropriate ICD therapy was observed in both groups, supporting the application of current ICD guidelines for primary and secondary prevention of sudden cardiac death in NCCM.

Original languageEnglish
Pages (from-to)898-904
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume22
Issue number8
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Implantable Defibrillators
Cardiomyopathies
Secondary Prevention
Primary Prevention
Sudden Cardiac Death
Ventricular Tachycardia
Heart Failure
Guidelines
Ventricular Fibrillation
Embolism
Cardiac Arrhythmias
Shock

Keywords

  • implantable cardioverter-defibrillator
  • noncompaction cardiomyopathy
  • primary and secondary prevention
  • sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Indications and outcome of implantable cardioverter-defibrillators for primary and secondary prophylaxis in patients with noncompaction cardiomyopathy. / Caliskan, Kadir; Szili-Torok, Tamas; Theuns, Dominic A M J; Kardos, A.; Geleijnse, Marcel L.; Balk, Aggie H M M; Van Domburg, Ron T.; Jordaens, Luc; Simoons, Maarten L.

In: Journal of Cardiovascular Electrophysiology, Vol. 22, No. 8, 08.2011, p. 898-904.

Research output: Contribution to journalArticle

Caliskan, Kadir ; Szili-Torok, Tamas ; Theuns, Dominic A M J ; Kardos, A. ; Geleijnse, Marcel L. ; Balk, Aggie H M M ; Van Domburg, Ron T. ; Jordaens, Luc ; Simoons, Maarten L. / Indications and outcome of implantable cardioverter-defibrillators for primary and secondary prophylaxis in patients with noncompaction cardiomyopathy. In: Journal of Cardiovascular Electrophysiology. 2011 ; Vol. 22, No. 8. pp. 898-904.
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abstract = "Prophylactic ICDs for Noncompaction Cardiomyopathy. Background: Noncompaction cardiomyopathy (NCCM) is a rare, primary cardiomyopathy, with initial presentation of heart failure, emboli, or arrhythmias, including sudden cardiac death. Implantable cardioverter-defibrillators (ICDs) are frequently used for primary and secondary prevention in different cardiomyopathy patients, but data about ICD in NCCM are scarce. The aim of this study was, therefore, to investigate ICD indications and outcomes in NCCM patients. Methods and Results: We collected prospective data from our NCCM cohort (n = 77 pts, mean age: 40 ± 14 years). ICD was implanted in 44 (57{\%}) patients with NCCM according to the current ICD guidelines for nonischemic cardiomyopathies: in 12 for secondary prevention (7 × ventricular fibrillation, 5 × sustained ventricular tachycardia [VT]) and in 32 patients for primary prevention (heart failure/severe LV dysfunction). During a mean follow-up of 33 ± 24 months, 8 patients presented with appropriate ICD shocks due to sustained VT after median 6.1 [1-16] months. This included 4 of 32 (13{\%}) patients in the primary prevention group and 4 of 12 (33{\%}) in the secondary prevention group (P = 0.04). 9 patients presented with inappropriate ICD therapy: 6 (19{\%}) in the primary and 3 (25{\%}) in the secondary prevention group, at a median follow-up of 4 (2-23) months. Conclusions: In our cohort of NCCM patients, an ICD was frequently implanted for primary or secondary prevention of sudden cardiac death. At follow-up, frequent appropriate ICD therapy was observed in both groups, supporting the application of current ICD guidelines for primary and secondary prevention of sudden cardiac death in NCCM.",
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AU - Geleijnse, Marcel L.

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AU - Van Domburg, Ron T.

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