Independent validation of the quality of life in essential tremor questionnaire (Quest)

Márton Kovács, Attila Makkos, J. Janszky, N. Kovács

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Quality of Life in Essential Tremor Questionnaire (QUEST) was specially developed for essential tremor population to measure the health-related quality of life. Besides the development of the Hungarian version, we performed an independent testing of the scale adding further information on its clinimetric properties. In this study 133 ET patients treated at University of Pécs, Hungary, were enrolled. Besides QUEST, we assessed Patient's Global Impression-Severity (PGI-S) and Fahn-Tolosa-Marin Tremor Rating Scales. After the independent validation in accordance to the Classic Theory of Tests, we evaluated cut-off values for detecting clinically meaningful ET-related disabilities based on receiver operating characteristics analysis. Cronbach's o was 0.897. QUEST demonstrated high convergent validity with PGI and divergent validity with disease-duration, positive family history, need for deep brain stimulation surgery, and the presence of depression and anxiety. Presence of moderate ET-related disabilities was identified by scores > 11.25 points on QUEST-SI (sensitivity: 77.4%, specificity: 83.3%); whereas scores > 20.35 points indicated severe ET-related disabilities (sensitivity: 83.3%, specificity: 59.1%). We demonstrated that the fundamental clinimetric properties of the QUEST are satisfactory.

Original languageEnglish
Pages (from-to)193-202
Number of pages10
JournalIdeggyogyaszati Szemle
Volume70
Issue number5-6
DOIs
Publication statusPublished - May 30 2017

Keywords

  • Essential tremor
  • Health-related quality of life
  • Reliability
  • Validity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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